Antibody-Based Treatments May Create Inflammatory Signs in Neurological Disorders

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Antibody-Based Treatments May Create
Inflammatory Signs in Neurological Disorders
Complete Neurological Care The team of scientists
led by Scripps Research Institute has discovered
that experimental antibody therapy for
Alzheimers and Parkinsons may adversely affect
brain inflammation. These antibody-based
treatments under the clinical trials for
neurodegenerative diseases showed that it might
trigger an inflammatory response in the human
brain immune cells. It erodes the positive
effects of antibody-based treatments.
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It is witnessed that antibody-based treatments
are designed to target the amyloid-beta and
alpha-synuclein that are the protein clusters
associated with the development of Alzheimers
and Parkinsons disease. This antibody-based
treatment was further shown to worsen brain
inflammation. These abnormal protein clusters
like alpha-synuclein and amyloid-beta are seen
to be associated with AD or Alzheimers disease
and PD or Parkinsons disease, and the antibody
treatments targeting these proteins have proved
unsuccessful under the clinical trials.
According to Stuart Lipton, MD, PhD., and the
Co-director of the Neurodegeneration New
Medicines Center at The Scripps Research, These
above findings and clinical trials have possibly
explained why these antibody treatments have not
succeeded against these neurodegenerative
diseases.
In one of the clinical trials, it was shown that
binding of the antibody to its target protein in
Parkinsons disease, where alpha-synuclein is the
target protein and leads to the pro-inflammatory
state in the human microglial cells. These
microglial cells are the immune cells of the
central nervous system. Both the PD and AD are
characterized by the formation of the
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protein clumps known as the aggregates, and they
will drive the disease progression too. According
to the clinical trials, it is stated, the small
sums of both these proteins known as oligomers
are known to be harmful to the nerve cells.
Stuart Lipton, who is also a clinical
neurologist, has stated, This is the first time
the researchers are examining the antibody-based
brain inflammation on the human brain. The
previous research findings were conducted for
the mouse brains, and the current studies are
using human brain cells.
The Board-Certified Neurologists are of the view
that these brain inflammatory responses may have
been overlooked in the past. Still, Dr. Lipton
states that these findings may show that the
benefits of antibody-based treatments are now
reversed.
Find a team of specialists who study
every pros and con before administering the
medications. So, it is advisable to take the
neurological treatments under the guidance of the
Board-Certified NYC
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