High-dose (600 to 1200 mg/day) oral magnesium treatment is effective in rapidly terminating depression, habituations, loss of intelligence, attention and memory, treating other neuroses including anxiety, hyper-emotionality, fatigue, panic, headaches,

1
Treatment prevention of side effects induced by
oral, high-dose magnesium therapy of mental
illnesses
George A. Eby and Karen L. Eby George Eby
Research Institute, 14909-C Fitzhugh Road,
Austin, Texas 78736 USA Email george.eby_at_george-eb
y-research.com
Discussion/Evaluation A number of clinical and
basic scientific studies on the effects of
magnesium in mental health have been reported

• 1921 Weston first reported that magnesium
  sulfate injections terminated agitated depression
  within a few hours. Magnesium sulfate (10
  elemental magnesium) was injected in doses of one
  to two CCs of a 25 or 50 solution resulting in
  nearly all of his fifty patients relaxing and
  sleeping from 4 to 6 hours.
• 2001 Papadopol et al. showed that stress from
  orphanage living drove down intracellular
  magnesium so severely that orphans lost much of
  their IQ. Magnesium deficit caused a number of
  neuropsychological disorders including,
  agitation, anxiety, depression, irritability,
  weakness, fatigue, confusion,
• asthenia, sleeplessness, headache, convulsive
  and nervous attacks, delirium, hallucinations and
  hyperexcitability.
• 2006 Eby and Eby reviewed the literature and
  suggested that high-dose magnesium treatment (800
  to 1200 mg /day) was effective for depression,
  traumatic brain injury, headache, suicidal
  ideation, anxiety, irritability, insomnia,
  postpartum depression, drug abuse, memory loss
  and IQ loss. Dietary deficiencies of magnesium,
  coupled with excess calcium and stress may cause
  many cases of other related symptoms including
  agitation, anxiety, irritability, confusion,
  asthenia, sleeplessness, headache, delirium,
  hallucinations and hyperexcitability, with each
  of these having been previously documented. The
  possibility that magnesium deficiency is the
  cause of most major depression and related mental
  health problems including IQ loss and addiction
  is enormously important to public health and is
  recommended for immediate further study.
• 2006 Enya showed that depression could be
  immediately relieved by IV injection of magnesium
  sulfate, while oral magnesium oxide was not
  effective.
• 2006 Eby demonstrated that magnesium throat
  lozenges were effective as rescue treatment for
  allergy-induced asthma in adults, producing
  rescue in minutes. However, a common cold
  treated with a single 100 mg magnesium (magnesium
  chloride) throat lozenge producing 100 mM
  salivary concentration lasted two months and was
  very severe.
• 2009 Eby hypothesized that magnesium throat
  lozenges would severely worsen rhinovirus-induced
  asthma - perhaps fatally - since 30 mM magnesium
  chloride was shown in the 60s to increase the
  release of rhinoviruses by 8- to 310-fold.
• NOTE Although magnesium over-dose is well known
  to produce diarrhea, very little was found
  concerning biologics-induced side effects of
  high-dose, oral magnesium treatment. However,
  our uncontrolled observations and the reports
  from others have convinced us that more
  consideration of its pro-herpes, pro-Candida
  albicans and pro-rhinovirus potential is needed.
  
• For example - anecdotally
• Treatment of active genital herpes infections
  with 100 mM magnesium chloride greatly worsened
  infections.
• Oral herpes was very greatly worsened upon use of
  100 mM magnesium chloride facial treatment.

Very Brief Overview of Literature
Results Oral magnesium-worsened Candidiasis
responds slowly to treatment. Viral infections
worsened by magnesium respond slowly to zinc
treatment.
Important Figures from the Literature

• Introduction
• High-dose (600 to 1200 mg/day) oral magnesium
  treatment is effective in rapidly terminating
  depression, habituations, loss of intelligence,
  attention and memory, treating other neuroses
  including anxiety, hyper-emotionality, fatigue,
  panic, headaches, migraines, insomnia and
  preventing suicide. Concentrated magnesium
  solutions without calcium exponentially worsen
  Candida albicans infections of the upper and
  lower gastrointestinal tract, increase rhinovirus
  release up to 310-fold at 30 mM concentration and
  greatly increase herpes-simplex viral count.
  Although immediately effective in treating adult
  allergy-induced asthma, magnesium throat lozenges
  greatly worsen rhinoviral common colds. Since
  rhinoviruses are a primary source of childhood
  asthma, use of magnesium throat lozenges in
  pediatric (or adult) asthmatics could be fatal,
  and they will also greatly worsen herpes simplex
  infections. Magnesium oxide is not brain
  bioavailable, and magnesium aspartate and
  glutamate are neurotoxic.

Conclusions Prevention and management of
biologics-induced side effects insures that
beneficial magnesium compounds will remain safe
and effective broad-spectrum mental health
treatments. Medical means of rapidly increasing
brain magnesium through use of IV drips,
injections, intracranial, intrathecal, rectal and
transdermal administration (usually magnesium
sulfate or chloride) need to be developed to
prevent biologicsinduced oral side effects of
magnesium, at least in the beginning of treatment.
Objectives To maintain efficacy, prevent side
effects, treat or prevent exponential growth
stimulating effect on Candida albicans in the
upper and lower gastrointestinal tract and
prevent worsening of rhinovirus and herpes
simplex viral infections.

• References
• Weston PG. Magnesium as a sedative. Am J
  Psychiat. 1921786378.
• Papadopol V, Tuchendria E, Palamara I. Magnesium
  and some psychological features in two groups of
  pupils (magnesium and psychic features). Magnes
  Res 200114 (1/2)2732.
• Eby GA, Eby KL. Rapid recovery from major
  depression using magnesium treatment. Med
  Hypotheses. 200667(2)362-70.
• Eby GA, Eby KL. Magnesium for treatment-resistant
  depression A review and hypothesis. 2009
  (pending).
• Eby GA. Rescue treatment and prevention of
  asthma using magnesium throat lozenges
  Hypothesis for a mouth-lung biologically closed
  electric circuit. Med Hypotheses.
  200667(5)1136-41.
• Eby GA. Hypothesis for risk of death or serious
  sequela from asthmatic use of magnesium throat
  lozenges due to 8- to 310-fold rhinovirus release
  increase by concentrated magnesium. Medical
  Hypotheses. 2009.
• Enya M, Kanoh Y, Mune T, et al. Depressive
  state and paresthesia dramatically improved by
  intravenous MgSO4 in Gitelman's syndrome. Intern
  Med. 200443(5)410-4.
• Holmes AR, Cannon RD, Shepherd MG. Effect of
  calcium ion uptake on Candida albicans
  morphology. FEMS Microbiol Lett. 199161187-93.
• Fiala M, Kenny GE. Effect of magnesium on
  replication of rhinovirus HGP. J Virol
  1967148993.
• Fiala M. Plaque formation by 55 rhinovirus
  serotypes. Appl Microbiol 196816144550.
• Eby GA. Zinc lozenges cold cure or candy?
  Solution chemistry determinations. Biosci Rep
  200424(1)2339.

Methods Only use beneficial magnesium
compounds. Treatment of oral magnesium-induced
Candidiasis includes therapeutic doses of calcium
(which may immediately worsen depression),
biotin, indole-3-carbinol, inulin, acid-resistant
probiotics (Bacillus coagulans), anti-diarrheal
agents and antifungals. Zinc acetate throat
lozenges (18 mg ionic zinc) may shorten common
colds and eliminate oral herpes infections
worsened by magnesium. Strong (100 mM) topical
ionic zinc gluconate solutions may effectively
treat herpes simplex skin lesions worsened by
magnesium.
Very little has been published concerning the
biologics-induced side effects of high-dose, oral
magnesium treatment. However, our uncontrolled
anecdotal observations and anecdotal reports of
others using high-dose magnesium to treat mental
illness have convinced us that more consideration
of the pro-herpes, pro-Candida albicans and
pro-rhinovirus potential is needed, with special
consideration of its adverse effects on the
intestinal tract.
If high-dose magnesium is to be optimally useful
in treating mental illness, it may need to be
administered using parenteral administration