ASIAPACIFIC INSTITUTE OF TROPICAL MEDICINE AND INFECTIOUS DISEASES

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Pacific Regional BioSafety Laboratory (PacRBL)
at Kakaako
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PacRBL

• PROTECT
• Hawaiis People Economy
• PREVENT
• Threats to Public Health Economic Well-Being
• PREPARE
• Equip Ourselves with TOOLS to Rapidly Detect
  Respond to Infectious Disease Emergencies

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Global Re-Emergence of Infectious Diseases

• PROTECT
• Early Detection
• Rapid Response
• PREVENT
• Research -Vaccines, Drugs, Diagnostics
• PREPARE
• Readiness

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PacRBL

• Early Detection
• The FASTER We Know What It Is
• Rapid Response
• The FASTER We Can Take Appropriate
• Action

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PacRBL Is a Partnership

• U.S. National Institutes of Health (NIH)
• University of Hawaii
• Hawaii Biotech (local biotech co.)
• U.S. Dept of Defense
• State Dept of Health
• State Dept of Business, Economic Dev and Tourism
• Hawaii Science Technology Council (trade group)
• Enterprise Honolulu (economic development group)
• Residents of Kakaako Community State of
  Hawaii

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Proposed PacRBL

• UH Awarded 25M from NIH 12.5M from State of
  HI
• Build State-of-the-Art BioSafety Lab in Hawaii
• Monitor Infectious Diseases Introduced to Hawaii
• Early Detection and Rapid Response
• Develop Drugs, Vaccines Diagnostic Tests to
  Protect Hawaiis People from Emerging
  Re-Emerging Infectious Diseases

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What Kind of Lab Will It Be?

• Level 3 Regional BioSafety Lab
• Infectious Agents Classified in 4 Levels
• Level 1 Non-lethal
• Level 2 Potentially lethal-Not Airborne
• Level 3 Potentially lethal-May be Airborne
• Level 4 Highly lethal- Airborne or Unknown
  Transmission

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What Kind of Lab Will It Be?

• Is NOT and Will NEVER BE Level 4
• Converting to Level 4 is NOT POSSIBLE Requires
  New Construction
• Part of NIH Network of BioSafety Labs
• 15 Similar Labs being Built by Other US
  Universities

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NIH/NIAID Supported National BioSafety
Laboratories (NBLSs) Regional BioSafety
Laboratories (RBLs)
Lack of Lab Capacity in Western U.S.
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Why does Hawaii Need a BioSafety Lab?

• Global Emergence/Re-Emergence of Infectious
  Diseases Pose Increasing Threats
• Avian Influenza, SARS, Dengue fever, West Nile
• Increased Threat of Biological Terrorism
• BioSafety Lab is Critical to Health Security of
  our Community, City, State, Nation World
• Research Needed to Understand How to Prevent,
  Control Treat Diseases

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Hawaii is Particularly Vulnerable

• Honolulu is One of 25 Central Cities in Global
  Airline Network
• Most Infectious Disease Emergencies in Past 12
  Yrs Originated in Asia
• Most Infectious Diseases Introduced Via Honolulu
  International Airport

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Hawaii is Particularly Vulnerable

• Hawaii DOES NOT Have Adequate Laboratory Capacity
  to Detect, Respond, or Prevent Introduced
  Infectious Diseases
• It is Not IF, But WHEN a Serious Infectious
  Disease Will be Introduced to Hawaii

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Impact of an Exotic Infectious Disease Epidemic
in Hawaii would be Devastating

• Public Health
• Economy

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What Type of Research Will be Done at PacRBL?

• Prevention Treatment of Infectious Diseases
• New diagnostics, drugs, vaccines, other
  prevention modalities
• Role of Bodys Immune System in Fighting
  Infectious Disease
• West Nile virus, dengue, influenza, TB, malaria,
  leptospirosis
• New Technologies
• Genomics, Proteomics, Microarrays

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What Type of Research Will be Done at PacRBL?

• Absolutely NO Bioweapons Research(Not
  Permissable Under International Law)
• NO Secret or Classified Research Only
  Publishable Research on Infectious Diseases
• PacRBL Research Info Will be Available to
  Community

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What are Physical Features of PacRBL?

• Custom Built to ensure SAFETY
• Approx. 38,000 sq ft in size
• Stringent Security Controls
• Physical Vehicle Barrier
• Attractive, Three-Story Stand-Alone Facility
• Exterior Design will Complement Existing JABSOM
  Buildings

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Preliminary Rendering of PacRBL in Kakaako
Many Factors will Impact Final Design of
PacRBL INCLUDING COMMUNITY INPUT
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Where will PacRBL be Located?
On Existing UH Leased Site Does NOT Encroach Upon
Other Areas
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Where will PacRBL be Located?
Access to Kakaako Waterfront Park Shoreline
WILL NOT BE OBSTRUCTED
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Why Kakaako JABSOM Campus?

• Pearl City Waimano Ridge Site Required 38M
  Additional Infrastructure Costs Time
• Other Considered Sites Problematic(Tripler,
  Manoa Campus, Ford Island, Barbers Point,
  Halawa)
• Remote Locations Not Selected
• Increased Costs
• Transport of Agents
• Limited Space
• Greater Proximity to Hospitals/Research Facilities

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Kakaako JABSOM Campus Is Ideal

• Part of Existing Medical Research Campus
• Synergy
• Increased Efficiency
• Cost Savings
• Builds Critical Mass
• Accelerates Life Sciences Vision of Kakaako
• Enables Future Collaborations
• Scientific Center of Excellence Magnet School
• Science Tech Mentorships/Internships

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SAFETY

• NO Infectious Disease Agents Have Ever Been
  Released from a U.S. BioSafety Lab

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SAFETY

• Flawless Track Record
• Ex. BSL3 -4 Labs in CO, GA, MD
• Operational for Decades
• Urban, Dense Population Centers
• Only Very Small Quantities of Agents
• Most Stringent Interpretation of Federal
  Guidelines for Design Operation
• Supervised by UH Institutional BioSafety
  Committee (IBC)

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CDC
Emory University
Georgia Tech
CNN Center
Georgia St Univ
State Capitol
Downtown - Atlanta, GA
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Emory University/ Residential
CDC Day Care Center
Residential
Emory University
CDC Bldg18
CDC Bldg15
CDC Roybal Campus, Atlanta, GA
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NIH, Bethesda
National Mall, Wash. DC
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NIH BSL4 (3), Bethesda, Maryland
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SAFETY

• 1 Concern in Developing BioSafety Labs
• For Environment Community
• For Scientists Working in the Lab At Greatest
  Risk

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SAFETY

• Extensive Safety Measures Built-In
• Negative Air Pressure
• HEPA Filters Clean 99.99 Bacteria Viruses
• Alternate Power Water
• Custom-Built Interior Surfaces/Bench Tops
• No Glass Containers
• Protective Clothing, Gloves, Masks

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SAFETY

• Researchers Trained to Prevent Accidents
• Precautionary Measures, Contingency Protocols,
  Vaccinated
• Strict Security Measures Built-In
• Labs Within Labs, Restricted Access, Secured
  Perimeter

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SAFETY

• Contingency Plans with Detailed Procedures Will
  Be In Place to Address Any Potential
  Problems/Emergencies
• Human Accidents
• Loss of Power
• Natural Events Tsunami, Flood, Hurricane

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What About Natural Disasters?

• Custom-Built Designed to WithStand Major
  Storms Other Natural Disasters
• Earthquake Has Never Damaged a BioSafety Lab
• Ex. Texas Rita, Tulane - Katrina

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What About Tsunami/Flood?

• Thorough Risk Assessment for Tsunami/Flood
• Environmental Assessment
• Actual Lab Space on 2nd Floor
• 1st Floor - Admin Offices
• 3rd Floor - Critical Auxiliary Equipment
• Elevated Emergency Generator Fuel Tank
• Tsunami Warning System In Place
• Researchers Mandated to Follow Comprehensive
  Contingency Plans Detailed Protocols

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What are the BENEFITS of the PacRBL to
Hawaii?To Hawaiis People?
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PacRBL is about Public Health

• PROTECT
• Hawaiis People Economy
• PREVENT
• Threats to Public Health Economic Well-Being
• PREPARE
• Rapid Detection Response to Introduced
  Infectious Disease Emergencies

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Global Infectious Diseases

• PROTECT
• Early Detection
• Rapid Response
• PREVENT
• Research Vaccines
• PREPARE
• Readiness

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PacRBL is about Our Public Health

• Early Detection
• The FASTER We Know What It Is
• Rapid Response
• The FASTER We Can Take Appropriate
• Action

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"Let me be clear. It is only a matter of time
before we discover H5N1 in America. The migration
patterns of the wild fowl that carry the virus
make its appearance here almost inevitable."
Michael LeavittU.S. Health and Human Services
SecretaryMarch 13, 2006 disasters are local
events and require local responses. The center of
gravity of the pandemic response will be in
communitiesWhite House Report National
Strategy for Pandemic InfluenzaMay 2006
WHEN Not IF
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Protect Grow Hawaiis Economy

• Safeguard Hawaiis Tourism Industry
• Increase Research Funding
• Build Hawaiis Life Sciences Industry
• Create High-Paying Jobs
• Attract Top Expertise
• Increase Prestige
• Facilitate Educational Partnerships
• Scientific Center of Excellence Magnet School
• Mentorships/Internships
• Stimulate Students Interest in Science Tech

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What is the Timeline?

• Sept 15, 2005 - NIH Grant Awarded to UH
• Oct 2005 - Mar 2006 - Detailed Site Assessments
• May 2006 - Revised Application Submitted
• July 5, 2006 - Site Change Approved by NIH
• May - Dec 2006 - Community Outreach,
  Planning, Environmental Risk Assessment
  
• January 2007 - Developer Selected Approved,
• Design Completed
• Summer 2007 - Contracts Set, Construction
  Begins
• December 2009 - Construction Completed
• Summer 2010 - Certification Completed

Facility Expected to be Operational In 2010
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Community Input Is Essential

• Comprehensive Community Outreach
• From Start to Finish
• AND WILL CONTINUE AFTER LAB IS OPERATIONAL
• Community is a Critical Partner
• We Need to Hear Understand Your Opinions,
  Concerns, and Suggestions

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Collaboration Transparency

• Community Involvement Input is Critical
• Proactive Outreach to All Interested
  Individuals/Groups
• Regular Updates to Any Interested Group (ex.
  Neighborhood Board 11)
• Broader Public Open Forums
• Email Updates, Informational Handouts
• We Will be Accessible, Reachable
• Regular Meetings with Key Community
  Stakeholders Group for Guidance Input

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Community Stakeholders Group

• Community Liaison Group for Guidance Input
• Open to Anyone
• Community Leaders
• Representatives from Community Groups
• Elected Officials Relevant Reps State/City
  Agencies
• Interested Residents
• UH Partner Organizations
• Continued Community Outreach After Lab Completion
• Updates to Neighborhood Board
• Updates on Website
• On-going Research Info Will be Available on UH
  Website

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Current Communication Materials

• PacRBL Powerpoint Presentation
• Frequently Asked Questions (FAQ)
• Informational Handouts, Mailings
• Press Releases
• Email Updates, Meeting Notices, Minutes
• Website www.hawaii.edu/pacrbl
• Ability to Email Questions Directly
• Online Blog (coming)
• CommunityYahoo Group http//groups.yahoo.com/group
  /pacrbl

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For Questions To Share Thoughts

• Community Liaison Ann H. Chung achung_at_hawaiisci
  techcouncil.org
• 547-5835
• Website www.hawaii.edu/pacrbl

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Q A