HOW CAN NEUROIMAGING HELP UNDERSTAND, DIAGNOSE, AND DEVELOP TREATMENTS FOR ALZHEIMER'S DISEASE? Part D1

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HOW CAN NEUROIMAGING HELP UNDERSTAND, DIAGNOSE,
AND DEVELOP TREATMENTS FOR ALZHEIMER'S
DISEASE?Part D1 AD brain scans perfusion
SPECT

• NUCLEAR MEDICINE GRAND ROUNDS
• Stanford University
• J. Wesson Ashford, M.D., Ph.D.
• Clinical Professor (affiliated), Department of
  Psychiatry and Behavioral Sciences
• Senior Research Scientist, Stanford / VA Aging
  Clinical Research
• Stanford University and VA Palo Alto Health Care
  System
• January 5, 2010
• Slides at www.medafile.com (Dr. Ashfords
  lectures)

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Relation of SPECT severity to duration of
dementia (years)Shih, Ashford et al., 2000
SPECT severity SPECT grade Dementia Duration
Normal 0 start 0 years
Near-Normal 1 1
Mild 2 2
Mild-moderate 3 3
Moderate 4 4
Moderate-severe 5 5
Severe 6 6
Severe-profound 7 7
Profound 8 8
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SPECT scans normalization to cerebellum on Left
to Right, to Talraich space
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SPECT scan locations of cortex, local elements
shown with Brodman areas, colored according to
correlation with estimation of dementia severity
(derived from the Mini-Mental State Exam)
Ashford et al, 2000
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