HOW CAN NEUROIMAGING HELP UNDERSTAND, DIAGNOSE, AND DEVELOP TREATMENTS FOR ALZHEIMER'S DISEASE? Part D2

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HOW CAN NEUROIMAGING HELP UNDERSTAND, DIAGNOSE,
AND DEVELOP TREATMENTS FOR ALZHEIMER'S
DISEASE?Part D2 AD brain scans metabolism -
PET

• NUCLEAR MEDICINE GRAND ROUNDS
• Stanford University
• J. Wesson Ashford, M.D., Ph.D.
• Clinical Professor (affiliated), Department of
  Psychiatry and Behavioral Sciences
• Senior Research Scientist, Stanford / VA Aging
  Clinical Research
• Stanford University and VA Palo Alto Health Care
  System
• January 5, 2010
• Slides at www.medafile.com (Dr. Ashfords
  lectures)

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Minoshima et al., 1997
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FDG-PET in AD and MCI
Courtesy of S. Minoshima, University of Washington
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The purple areas are regions in which glucose
metabolism was significantly reduced only in the
group with probable Alzheimer's disease, the
blue areas regions in which glucose metabolism
was significantly reduced in both the 4
homozygotes and the patients with probable
Alzheimer's disease, and the green areas
regions in which glucose metabolism was
significantly reduced only in the 4
homozygotes.
Regions of the Brain with Reduced Rates of
Glucose Metabolism in 11 e4 Homozygotes and
Their Relation to Brain Regions with Reduced
Glucose Metabolism in 37 Patients with Probable
Alzheimer's Disease. Reiman et al., 1996