Biocidal Materials for Public Health and Consumer Products (Overview)

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Biocidal Materials for Public Health and
Consumer Products(Overview)

• Available Through
• TETRAD Technologies Group, Inc.
• Contact Dr. Martin Dudziak, PhD
• martin_at_forteplan.com
• [phone]
• [phone]
• [phone] cell

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An Anti-Microbial Monomer/Polymer Offering
Cleaner, Faster, Safer, More Comprehensive
Anti-Microbial Protection

• Not a serious toxin and danger like Triclosan
• Cheaper, faster-acting than silver/copper-based
  compounds
• Non-leaching stays within the material
• Extends functional life of product treated
• Produces self sanitizing materials
• Can be applied as spray, in solution, or as
  powder

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Benefits

• Non- leaching, permanent antimicrobial surface
• Biocide has been proven to be nontoxic, to
  contain no carcinogens, teratogens, mutagens or
  reproductive toxins
• Active kills instantly by disrupting the cell
  membrane, eliminating any possibility of
  mutation, adaptation or resistance
• Broad kill range
• Environmentally friendly-EPA and FDA approved
• The technology can be used on wide range of
  materials.
• Provides both collective and individual
  bio-defense protection.
• Added cost is modest compared to benefit.
  Approximately 2-5 cents per square foot of
  coating or 5 to 50 cents per pound of plastic or
  resin.

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Typical Applications

• Individual and collective protection
• Clothing, Uniforms, and other Wearable Fabrics
• Carbon filters
• Tent Webbing and canvas materials
• Painted Surfaces
• Laminate and counter tops in field operations
• Contamination avoidance
• Bulk polymer Resins/ Plastics
• Resin Concentrates
• Sanitation and Health Safety Equipment
• Medical treatment
• Medical Devices
• Surgical drapes and wound dressings
• Nano coatings
• Interior surfaces/ walls floors
• HVAC ducts
• Filters

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Action The Poly-Quat AntimicrobialIs bound to
the product controlling Microbes on contact

• Is substantive to the product substrate
• Is not consumed when challenged by microbes
• Mechanically destroys the cell
• Will not cause microbial adaptation
• Functions equally in a nano coating or bulk
  substrate treatment process
• Can be added into manufacturing process or
  applied later
• Can be combined with other surface protectants
  (e.g., water repellant, anti-static)

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The Antimicrobial AgentWhy did we choose this
antimicrobial?

• 3 (trimethoxysilyl)propyldimethyloctadecyl
  ammonium chloride
• Unique in the scope of its kill range/broad kill
• Bacteria (gram positive)
• Staphylococcus Aureus
• Bacteria (gram negative)
• Salmonella Typhosa
• Yeast
• Algae
• Fungi
• EPA Registered
• Chemically active

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Antimicrobial Treatment Improves Fiber Strength

ASTM standard D2256-02 Tensile Strength
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Antimicrobial JSLIST Fabric
Sample ID Log Kill
(1) JSLIST w/ 0.2 HM-4072 6.48
(2) JSLIST W/ 0.20 HM-4072 Triton X-100 6.47
(3) 65/35 Polyester/cotton W/ 0.2 HM-4072 and 3.6 Zonyl 7040 gt7.41
(3) Boiled in water 5 min 7.22
(3) Laundered 6 times 6.32
(4) 100 Cotton w/ 0.2 HM-4072 and 3.6 Zonyl 7040 7.12
(4) Boiled in water 5 min 7.07
Dynamic Shake Flask Test E. coli, one hour,
sample size 2.5 X 2.5 cm
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Repeated Exposure of Treated fabric to E. coli
Dynamic Shake Flask Test-E. coli 2.5 cm Sample
One hour contact time
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Tent Webbing Soil Burial TestPoly Quat
Percent Strength Remaining After Soil Burial
Time Control 1 Poly-QUAT
0 100 100
Week 1 118 105
Week 2 112 105
Week 3 80 99
Week 4 63 120
Week 5 35 99
Week 6 30 108
Week 7 Dis 86
Week 8 Dis 85
Week 9 Dis 76
ASTM 30-1999
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Antimicrobial Activated Carbon
HM 4072 Poly-Quat Log Kill CTC
0.1 None 77.6
0.25 6.11 73.4
0.5 6.26 75.4
0.05 5.92 75.4
0.01 5.75 77.0
0.25 6.18 78.0
0 (Control) 0 (control) 1.11 E6 (cfu/mL) 79.5
Dynamic Shake Flask Test E. coli, one hour,
sample size 2.5 X 2.5 cm Colony forming units
in starting broth. The control exhibits no kill.
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Polymer Applications
Material Log Kill 0.2 active
PVC 6.69
HDPE 6.35
Melamine/formaldehyde 7.1
Polyurethane 6.44
PVOH 5.54
Dynamic Shake Flask Test-E. coli 2.5 cm Sample
One hour contact time
Dynamic Shake flask test, E. coli
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Anthrax Surrogate Bacillus Cereus
Identification Form Log Kill
Textile/PVOH Cells No Kill
Textile/PVOH/L-alanine Cells No Kill
Textile/PVOH/L-alanine Cells No Kill
Textile/PVOH/0.2 HM4072/L-alanine Cells 5.79
PVOH cast film/0.2 HM4072/L-alanine Cells 5.77
PVOH cast film/L-alanine Spores No Kill
PVOH cast film/0.2 HM-4072/L-alanine Spores 4.16
Dynamic Shake Flask Test-E. coli (1.06E06) 2.5
cm Sample One hour contact time
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Resin Coating Systems
Resin System Poly Quat Log Kill
Water Acrylic Melamine/ Al 0.1 4.73
0.25 5.30
Water Borne Acrylic Urethane/ Al 0.2 3.6
0.4 4.34
0.4 aged 1 week 5.55
Dynamic Shake Flask Test-E. coli 2.5 cm Sample
One hour contact time
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HM 4072 Sanitizing Nano Coating
Surface Log Kill
Aluminum 0.2 from IPA gt7.08
Aluminum 0.2 from Water 7.08
Aluminum 0.2 From Water Leached 1 Hr 4.55
Aluminum 0.02 from IPA 7.08
Stainless Steel 0.2 From Water 5.90
Glass Slides 0.2 from Water 6.24
Laminate 0.2 from Water 6.31
Dynamic Shake Flask Test-E. coli 2.5 cm Sample
One hour contact time
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Untreated Control surface
Treated surface
Dead Bacteria
Living Bacteria
Octadecylaminodimethyltrihydroxy-silylpropyl
Ammonium Chloride
C
H
OH
3
-
Cl

HO
Si
N
C
H
3
C
H
3
OH
Substrate surface