Perception and Memory in the Medial temporal Lobe: Insights from Anatomy and Physiology

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Perception and Memory in the Medial temporal
Lobe Insights from Anatomy and Physiology
Wendy A. Suzuki Center for Neural Science New
York University
MDRS Chapel Hill, NC 9/25/09
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Talk Outline

• Neuroanatomy of the PRC and area TE
• Physiology of the PRC and area TE
• Future experiments

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Ventral View of Macaque Monkey Brain
TE
PH
PR
rs
ER
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DG
HPC
Sub
Entorhinal
Parahippocampal
Perirhinal
Suzuki and Amaral, 1994
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Cortical Inputs to the Perirhinal Cortex
TE/TEO 63
STSd 6
TF/TH 25
Insula 2
Frontal lobe 2
Cingulate/Retrosplenial lt1
V4 2
Perirhinal Cortex
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Cortical Inputs to Area TE
Frontal area 8 and 45
Orbital areas 11 and 13
Perirhinal
Parietal (LIPd)
Area TE
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DG
HPC
Sub
Entorhinal
Parahippocampal
Perirhinal
Suzuki and Amaral, 1994
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What about the cytoarchitectonic features of
these areas?
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DG
HPC
Sub
Entorhinal
Parahippocampal
Perirhinal
Suzuki and Amaral, 1994
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Talk Outline

• Neuroanatomy of the PRC and area TE
• Physiology of the PRC and area TE
• Future experiments

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Pair Coding response
Individual cell responses in area 36
Naya et al., 2003
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Behavioral Learning Curve and Delay Activity
Over Time to Scene 653
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0.8
0.6
Probability Correct
0.4
0.2
0
0
10
20
30
40
50
Wirth et al., 2003
Trials
C110600.4
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Object-Place Association Task
Wirth et al, 2009
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Conclusions

• Pair coding neurons are built in the perirhinal
  cortex from the sensory input from area TE.

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Talk Outline

• Neuroanatomy of the PRC and area TE
• Physiology of the PRC and area TE
• Future experiments

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Experiments?