Reporting Status or Progress

1
Daniel R. Kapusta, Ph.D. Department of
Pharmacology, LSUHSC MEB Rm 7106 568-3940
dkapus_at_lsuhsc.edu
Renal Transport of Sodium, Chloride and other
Solutes
2
Total Body Sodium Balance Input Output
3
Renal excretion of sodium
4
Renal handling of water, electrolytes and solutes
5
Renal handling of sodium
6
Renal process involved in the production of urine
1) Glomerular filtration
2) Renal tubular secretion
3) Renal tubular reabsorption
7
Glomerular filtration
8
Tubular secretion
9
PCT organic acid secretory transport system
10
PCT organic base secretory transport system
11
Tubular filtration and reabsorption
Average Values for Several
Substances Handled by
Filtration and Reabsorption Amount Filtered
Amount Substance per
Day Excreted Reabsorbed Water, L
180 1.8 99.0 Sodium, g 630
3.2 99.5 Glucose, g 180 0 100
Urea, g 56 28 50
12
Segmental renal tubular sodium reabsorption
13
Tuboglomerular feedback regulation of sodium
chloride excretion
14
Juxtaglomerular apparatus (JGA)
15
Regulation of sodium excretion Glomerulotubular
balance
16
Glomerulotubular balance
17
(No Transcript)
18
Transport pathways across tubular cells
19
Sodium, glucose and bicarbonate reabsorption in
the proximal convoluted tubule
20
Renal tubular reabsorption of glucose
21
- Diuretics are drugs that increase the net
excretion of water from the body
- Diuretics increase the rate of urine
formation by interfering with the reabsorption of
sodium by the nephron
- The increase in sodium loss in the urine, a
natriuresis, causes water to follow and thus
produce diuresis
22
Mannitol
23
(No Transcript)
24
Carbonic Anhydrase
Carbonic Anhydrase
25
(No Transcript)
26
(No Transcript)
27
Electrolyte transport pathways in the TALH
28
(No Transcript)
29
(No Transcript)
30
Sodium and chloride reabsorption in the early
distal convoluted tubule
31
(No Transcript)
32
(No Transcript)
33
Sodium - potassium exchange in the late distal
convoluted tubule
34
(No Transcript)
35
(No Transcript)
36
(No Transcript)
37
AVP-dependent water permeability in the distal
nephron
38
Vasopressin mediated water reabsorption