Alzheimer Disease Assessment ScaleCognitive Subscale ADAScog 11Item - PowerPoint PPT Presentation

Title: Alzheimer Disease Assessment ScaleCognitive Subscale ADAScog 11Item


1
Alzheimer Disease Assessment ScaleCognitive
Subscale (ADAS-cog) 11-Item
Increasing scores indicate worsening cognitive
function.Rosen WG, et al. Am J Psychiatry.
19841411356-1364.
2
Treatment Difference at Wk 24 on ADAS-cog by
CountryCore StudyITTRDO Population
Austria (N 9)
Belgium (N 21)
Canada (N 41)
Germany (N 63)
Spain (N 59)
France (N 63)
Great Britain (N 48)
Italy (N 118)
Netherlands (N 18)
39.67
46.92
Norway (N 7)
29.92
Portugal (N 9)
Turkey (N 45)
10
0
10
20
20
Favor Exelon
Favor placebo
LS mean difference (95 CI).
3
Duration of Nausea and Vomiting and Number of
Events per PatientCore Study
Events with no end dates recorded, which may or
may not have resolvedby last study visit.
4
Duration of Tremor and Number of These Events per
PatientCore Study
1 episode 34 patients 2 episodes 3 patients.
Events with no end dates recorded, which may or
may not have resolved by last study visit.
5
AE of Tremor Over TimeCore and Extension Studies
Patients are counted more than once if event
continues through multiple periods.
6
Change on ADAS-cog Sub-items at Wk 24Core
StudyOC Population
p lt 0.05 p value based on van Elteren test
blocking for country.
7
Major Protocol ViolationsCore Study
8
Dopaminergic AgentsDose Increase After Start of
Study DrugCore Study
Doses were required to remain unchanged unless
clinically indicated.