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URAT1 = urate/anion exchanger in brush-border membrane of kidney. hOAT1 = human organic anion transporter (inhibited by uricosuric drugs) ...
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Uric Acid, Hyperuricemia, and Gout _____ Uric acid (urate) end product of purine degradation
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Recognize risk factors for hyperuricemia and gout, including major disease associations ... Gout is a disease characterized by hyperuricemia and monosodium ...
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Gout. Primary hyperparathyroidism. Prolonged immobilization. RTA. Excess dietary meat ... Gout. Low urinary pH. Malignancy. Treatment. Allopurinol for hyperuricemia ...
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Chronic Tophaceous Gout. Hyperuricemia untreated ... Treatment of Gout Attack. Continued. Dietary Management. Drink 3-4 quarts of fluids daily ...
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Hyperuricemia- gout, renal impairment. Chronic Myeloid Leukemia: Chronic Myeloid Leukemia: ... MPS : M.F. - Gout. MPS : MF - Marrow fibrosis. MPS : MF ...
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Hyperuricemia- gout, renal impairment. Chronic Myeloid ... MPS : M.F. - Gout. Ignorance is ignoring to change' Intelligence is making that right change. ...
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allopurinol intolerance before entry. efficacy and safety (clinical labs) ... Symptomatic hyperuricemia with documented allopurinol intolerance. Exclusion criteria: ...
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Caused by deposition of monosodium urate crystals around and in the tissues ... asymptomatic hyperuricemia; b)acute intermittent gout; c)chronic tophaceous gout ...
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Gout. Gout. Recurrent arthritis caused by hyperuricemia ... Chronic gout can result in deposition of urate crystals in the soft tissue ... Gout. Imaging Findings: ...
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Hyperuricemia, leading to attack of gout. Ethambutol (EMB) ... Other forms of treatments being implemented to cure the XDR and MDR forms of TB ...
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Pathogenesis of Gout. Hyon K. Choi, MD, DrPH; David B. Mount, MD; and ... advantages of the relative hyperuricemia in primate species have been speculated. ...
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LSU Clinical Pharmacology Drug Therapy of Gout Reginald D Sanders, MD Allopurinol - serious reactions fever, rash, toxic epidermal necrolysis hepatotoxicity, marrow ...
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60% of untreated gout have attacks within 1 yr , 78% have recurrence in 2 yrs, ... Patients with acute gout miss 3-5 days of work annually. ...
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Reduction of ribonucleoside diphosphates
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... . febuxostat - xanthine oxidase, . - ...
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... patients who have a first attack of gout should undergo therapy with agents that lower uric acid Some rheumatologists advocate waiting for the second attack to ...
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Review the clinical features of gout ... Annual Gout Prevalence Among All Enrollees by Age Group 1990-1999. J ... Why do people still suffer from gout? ...
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... time Drugs used to treat gout allopurinol probenecid febuxostat? steroids NSAID s colchicine Acute Arthritis Drugs Urate Lowering Drugs For chronic cases ...
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Drug Therapy of Gout Gout - urate-lowering therapy prevents arthritis, tophi & stones by lowering total body pool of uric acid not indicated after first attack ...
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the lower incidence and later onset of gout in women is attributed to more ... McCarty DJ. Rheum Dis Clin North Am 1988;14:253. Septic arthritis. ...
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... DM, hyperlipidemia, hematologic malignancies; ... Non Drug Therapy in Gout Diet Issues Drugs for Acute Gout Drugs for Acute Gout Drugs to Prevent Gout and ...
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Gout is a syndrome caused by the inflammatory response to tissue deposition of ... Acute gout is most likely secondary to the formation of new crystals. ...
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Asparate Ribose 5-phosphate PRPP Phosphoribosyl amine IMP ... Nucleotidases Nucleoside phosphorylases Deaminases Xanthine oxidases 3. the final common ...
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PURINE & PYRIMIDINE METABOLISM dr Agus Budiman * * * * * * * * * * * * * Nucleotide consists purine / pyrimidine base, ribose/deoxyribose and phosphates.
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TAP PHARMACEUTICAL PRODUCTS INC. Arthritis Drugs Advisory Committee ... TAP PHARMACEUTICAL PRODUCTS INC. No existing guidance on PROs for gout clinical trials ...
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Title: Pharmacology Author: zcy Last modified by: Created Date: 8/24/2002 2:50:00 AM Document presentation format: (4:3)
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DIURETICS Diuretics are drugs which increase the excretion of sodium and water from the body by an action on the kidney. Their primary effect is to decrease the ...
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Overall disease burden of gout is substantial and increasing ... Chronic tophaceous gout-develops after years of acute intermittent gout, ...
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Uromodulin and kidney disease: a new entry for an old molecule
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Joints (arthritis) Rheumatoid arthritis. Inflammatory dz affecting synovial ... Bone on bone crepitus. Try injected corticosteroids for anti-inflammation ...
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... with combination tx 3.3% hyperkalemia in monotherapy Creatinine doubled in 2.1%-combination tx Combination therapy showed ... of Incident Gout and ...
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Biochemistry
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First characterized by Michael Lesch & William Nyhan in 1964 ... http://embryology.med.unsw.edu.au/Defect/ images/lesch-nyhan_syndrome.jpg. Signs & Symptoms ...
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Probability that all tumor cells will be sensitive to a drug as a function of size of the tumor ... Acute: electrocardiogram changes, arrhythmias within hours ...
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High blood pressure. Dyslipidemia. Hyperglycemia. Also considered: Insulin resistance ... (3) Blood pressure 130/85 mm Hg (4) Triglycerides 150 mg/dL (5) HDL-C ...
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Introduction to Molecular Biology
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Targeted Enzyme Therapy of Cancers in Humans
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A woman does not take the gout unless her menses are stopped. ... 84% had at least one episode of podagra. 90% had podagra or attack involving the foot ...
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Title: Prediabetes Author: Carol Wysham Last modified by: burchett Created Date: 6/9/1998 2:55:14 PM Document presentation format: 35mm Slides Other titles
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Class III: Preeclampsia-eclampsia Superimposed Upon Chronic Hypertension Diagnosis should not be based solely upon increases in blood pressure.
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Spectrum of kidney diseases in malignancy Ayman El-Sebaie, MRCP(UK) Head of Nephrology Dept., IMC INTRODUCTION Patients with malignancy are particularly vulnerable to ...
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IRRADIATION. SURGERY. SYMPTOMATIC: 24 HOUR RULE. DEXAMETHASONE. SURGERY (ESP. ... emergency irradiation /- chemotherapy. SKIN EXTRAVASATION OF VESSICANTS ...
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... (FAD in barbiturate poisoning To counteract low plasma osmolality after dialysis Mannitol -Adverse Effects Acute Intravascular volume expansion Before ...
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Interacts with adenosine (purinergic) receptors ?1, ?2 , ?3 ... Test Bronchoconstrictor. Marta Segerdahl. Alf Sollevi. Karolinska Institutet, Stockholm ...
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Title: PowerPoint Presentation Last modified by: dpc6 Created Date: 1/1/1601 12:00:00 AM Document presentation format:
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Joints (arthritis) Rheumatoid arthritis Inflammatory dz affecting synovial joints predominately Hyperplasia of synovial fibroblasts Severity is varied
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To delineate the diagnosis and indications for treatment ... Putative mechanisms for chronic monosodium urate-induced inflammation and ...
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29 Drugs Used to Treat Musculoskeletal Conditions
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Oncologic Emergencies
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