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... in a Ristocetin-Induced Platelet Aggregation (RIPA) test (Howard MA, Firkin BG. ... Dr Barry Firkin. History of Ristocetin -1. Revised: mmv. M Ledford-Kraemer. 3 ...
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... traditionally been assessed by the use of the ristocetin cofactor assay (VWF:RCo) ... should not replace the ristocetin cofactor assay but rather be used in ...
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Haematology and Cell Biology, University of the Free State & NHLS, Bloemfontein ... Haemophilia, vol. 8, pp. 607-621. REFERENCE. LABORATORY DIAGNOSIS. Clinical History ...
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Platelet structure 1 Membrane glycoproteins IIb-IIIa: integrin, cryptic in resting platelet, after platelet activation binds fibrinogen and other adhesive proteins ...
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von Willebrands Disease Robert Gosselin MT (ASCP), CLS von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and ...
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... Shortened platelet life span Macroplatelets Poor response to platelet transfusion Causes Immune ITP Lymphoma Lupus/rheumatic diseases Drugs Consumption ...
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A RAPID METHOD TO ANALYSE VON WILLEBRAND FACTOR MULTIMERS ... Haemophilia, vol. 8, pp. 607-621. REFERENCE. LABORATORY DIAGNOSIS. 1. Clinical History ...
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Von Willebrand Disease vWF: enhance production of FVIII protect FVIII binding platelet (GPIb/IX) and collagen in subendothelium ...
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Column: CHIROBIOTIC T in Reversed Phase Mode. Mobile Phase: 40/60: MeOH/0.1% TEAA, pH=4.1 ... CHIROBIOTIC T vs R. FMOC Aspartic acid. Mobile phase: 40/60: MeOH ...
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LABORATORY DIAGNOSIS OF BLEEDING DISORDERS Primary & Secondary Hemostasis Disorders CIRCULATORY SYSTEM Low volume, high pressure system Efficient for nutrient ...
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Overview of primary hemostasis * Release : - dense granules ( ADP, ATP, ionized calcium, magnesium, epinephrin ...
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HEMOSTASISTHROMBOSIS II
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What is role of lab testing in evaluation and management of HIT? Is ... Afebrile, BP=124/82 mmHg. Few petechia on legs, ecchymosis on thigh. Lab studies ...
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Circular dichroism spectroscopy CD spectrum Unorientated chiral molecule CD = Al Ar The difference in absorbance of left & right circularly polarised light
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Outline 1. Introduction 2. Body Hemostasis Platelet disorder - Disorder of Plt function - Thrombocytopenia Inherited coagulation disorder - Hemophilia
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Skin purpura, which arises either spontaneously or secondary to trauma. The type of rush is petechial-bruise. ... anaphylactoid purpura, allergic angiitis, ...
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Title: PowerPoint Presentation Last modified by: biochem2 Created Date: 1/1/1601 12:00:00 AM Document presentation format:
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Platelet factor 4 c. Factor XIIII d ... no aggregation On patient s plt rich plasma sample used to ... therapy Plasma is diluted in a fibrinogen ...
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Paris-Trousseau platelets: a manifestation of Jacobsen syndrome. Interesting Case ... Paris Trousseau Syndrome. Isoummune thrombocytopenia ...
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von Willebrand s Disease December 3, 2004 Outline vWF Structure Location Function vWD History Clinical manifestations Categories Diagnosis Treatment vWD Family of ...
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vWF is produced as a propeptide which is extensively modified ... Post-operative 20% vWD Type I. Mild to moderate disease. Mild quantitative deficiency of vWF ...
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Coagulation & Hemostasis Part I Inherited Thrombocytopenia WAS/XLT: small platelets, poor platelet function vWD 2B: platelet clumping on ...
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6. Effect of stress, pregnancy, drugs. 7. Effect of PCV on the ... Kaolin clotting time. Dilute Russel's viper venom time. Platelet neutralization test ...
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Marfan syndrome: connective tissue. Osteogenesis imperfecta. Acquired Vascular Problems ... HELLP syndrome (hemolysis, elevated liver enzyme, low PLT) in pre ...
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White blood cell disorders Leukopenia Neutrophenia Lymphocytopenia Leukocytosis Granulocytosis Lymphocytosis Neoplastic proliferations of white cells
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Title: PowerPoint Presentation Author: OB/GYN Last modified by: OB/GYN Created Date: 4/3/2005 1:02:41 PM Document presentation format: On-screen Show
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Pathophysiology, diagnosis, treatment of thrombotic microangiopathy ... No diarrheal prodrome. Complement regulatory defects in some. Idiopathic TTP Demographics ...
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A DIAGNOSTIC ALGORITHM FOR INHERITED THROMBOCYTOPENIAS Carlo L. Balduini Dep. of Internal Medicine IRCCS Policlinico S. Matteo-University of Pavia, Italy
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Levels are increased in thrombocytopenia,and reduced in thrombocytosis. ... Wiscott Aldrich syndrome. Acquired. Immunothrombocytopenia. Thrombotic thrombocytopenic ...
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Are you a bleeder? surgical challenges. accidents & injuries. dental extractions ... patients range from asymptomatic to spontaneous bleeding similar to a ...
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Title: Kanamal hastaya yakla m Author: OKAN OZCAN Last modified by: yerdenizden Created Date: 10/29/1998 1:37:41 PM Document presentation format
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MLAB 1227- Coagulation ... and arachidonic acid Lab Testing For Secondary Hemostasis Disorders Purpose Evaluates coagulation factors Detects inhibitors ...
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PLATELET DISORDERS Nazzal Bsoul,MD Clinical Manifestations Common: mucocutaneous bleeding at birth or early infancy(gum bleeding, epistaxis ...
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Levels are increased in thrombocytopenia,and reduced in thrombocytosis. ... Skin purpura, superfacial bruising, epistaxis, menorrhagia. ...
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Wiskott-Aldrich syndrome. Syndromic MYH9-related disease ... (mild form of Wiskott-Aldrich) Diagnostic confirmation: SDS-PAGE. flow-cytometry ...
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Slide 1 ... Hematology Data
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Young woman with a bleeding diathesis. JM: 24 y.o W/F with history of severe ... subjective symptoms, NO evidence for a major bleeding diathesis. Coagulation ...
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Trousseau's syndrome. Heparin-associated thrombocytopenia. Eli Moschcowitz (1879-1964) 'In hospitals, people should be treated and not diseases. ...
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Title: CAUSES OF BLEEDING Last modified by: Eliot Williams Document presentation format: Custom Other titles: Times New Roman Arial SPC MarkersBullets Wingdings ...
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Dr.Mahmoodzadeh Hemathologist-Oncologist
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Bleeding disorders is a general term for a wide range of ... in which he wrote of an Andalusian family whose males died of bleeding after minor injuries. ...
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Retina before and after plasmapheresis in a patient with ... M5: Acute Monocytic Leukemia; NSE positive. M6: Erythroleukemia. M7: Megakaryoblastic Leukemia ...
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... tests estimate the risk of the baby having Down syndrome. ... Many children with Down syndrome have health complications beyond the usual childhood illnesses. ...
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3 less important factors include: complement, kinins and serine ... Contact between blood vessel , plts and ... Contractile proteins. Platelet kinetic, ...
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Whole blood is subjected to high shear and the closure time is measured ... The clot used in the clot retraction procedure should be kept at 37oC and ...
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Often can detect atrophic endometrium, leiomyomas, and endometrial polyps ... Directed biopsy or treatment possible (e.g., polyp excision) Perimenopause. H&P ...
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General Hematology Gao Qingping Department of Hematology Overview ( Definition 1 Hematopoietic system (1)Blood (2)Hematopoietic organ A prior to ...
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HAEMOPHILIA A, HAEMOPHILIA B & von WILLEBRAND'S disease ... Russells viper venom. Antifibrinolytic agents. Factor VIII concentrates. Human and porcine ...
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Hematology: Inherited blood disorders, case histories and review Michael R. Jeng, MD Tuesday, August 2, 2005 HPI: A 14 year old Nigerian boy, who is visiting the bay ...
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Front-to-back wiping with warm water after a bowel movement ... Aetiology - falls on to pointed object, fence post, bed post. Hymeneal injuries may occur ...
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CAUSES OF BLEEDING Defective clot formation Platelet plug Fibrin clot Excessive fibrinolysis Vascular fragility PLATELET DEFECTS Thrombocytopenia Increased ...
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The body's intrinsic ability to slow down or stop hemorrhage ... PF-3 serves as a binding site for cofactor V & VIII. production of thrombin. C. O. L. L ...
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Discounted Coagulation Profiles
