Comparative genomics of Streptomyces species

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Comparative genomics of Streptomyces species

• Alan Ward
• University of Newcastle upon Tyne

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Spore chain morphology Spiral
Spore chain morphology of S. violaceoruber
A3(2), 400X
Scanning electron micrograph of member of S.
violaceoruber clade, 9080X
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Streptomyces coelicolor A3(2) vs Streptomyces
albidoflavus
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Streptomyces violaceoruber as a model clade
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Streptomyces coelicolor genes absent from
members of the S. violaceoruber clade
Significantly under-represented on stringent,
competitive, array hybridisation
Streptomyces coelicolor genes absent in S.
lividans Manchester Colin Smith
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Rep-PCR of S. violaceoruber clade and isolates
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W3443 A3(2) parent S. tuirus 25 DNADNA
similarity CH999 A3(2) with actinorhodin
cluster with S. coelicolor
A3(2) deleted
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Presence of genes identified as unique to S.
coelicolor from whole genome comparison with S.
avermitilis in related strains