Development

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Development

• WHO - cell fate determination
• WHAT - cell differentiation
• WHERE - cell migration
• WHEN - timing of cell differentiation

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Role of the bunched gene in establishing the
centripetal migrating FC

• WHO morphogen Dpp instructs CMFC
• WHAT tissue-specific expression of transcription
  factors specify CMFC fate
• WHERE path CMFC migrate directed by
  nuclear-specific gene expression in syncytium?
• WHEN steroid hormone regulation of CMFC
  migration?

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Role of the bunched gene in establishing the
centripetal migrating FC

• WHO morphogen Dpp instructs CMFC
• WHAT tissue-specific expression of transcription
  factors specify CMFC fate
• WHERE path CMFC migrate directed by
  nuclear-specific gene expression in syncytium?
• WHEN steroid hormone regulation of CMFC
  migration?

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Overview of oogenesis
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Dpp patterns CMFC
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CMFC gene expression specified by Dpp
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Bunched
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Bunched antagonizes CMFC fate
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Bunched is required at the CMFC boundary