Pathways to discovery: personal and scientific lessons

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• Pathways to discovery personal and scientific
  lessons
• from my studies of Pemphigus??? John R.
  Stanley, M.D.Milton B. Hartzell ProfessorChair,
  Department of DermatologyUniversity of
  Pennsylvania Health System (UPHS)
• Philadelphia, Pennsylvania, USA
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Guest Lecture from Visiting Professor Pathways
to discovery personal and scientific lessons
from my studies of PemphigusJohn R. Stanley,
M.D.Milton B. Hartzell ProfessorChair,
Department of DermatologyUniversity of
Pennsylvania Health System (UPHS) Tuesday,
September 29th, 2009, 2.00-3.00 pm.Atthasit
Room, 5th floor, Sirikit Medical
centerRamathibodi Hospital
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John R. Stanley, M.D.Milton B. Hartzell
ProfessorChair, Department of Dermatology
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• Education
• 1970        B.A.        Cornell University1974
         M.D.        Harvard Medical School
  Clinical Specialties
• Autoimmune blistering skin diseases Research
  Area of Interests
• Immunodermatology, cell and molecular biology of
  keratinocyte adhesion, targeted drug delivery.
  Research Summary
• Dr. Stanley studies the pathophysiology of
  pemphigus, an autoimmune disease in which
  autoantibodies cause loss of keratinocyte cell
  adhesion and blister formation. He has shown that
  pemphigus antigens are desmosomal cadherins, and
  has shown that these glycoproteins function in
  stabilizing cell-cell adhesion in desmosomes.
  Furthermore, he has characterized the
  distribution of desmosomal cadherins in the skin
  and mucous membranes. Using this knowledge he has
  dissected the molecular pathophysiology of these
  diseases. By altering the distribution of
  desmosomal cadherins he has shown protection
  against disease and determined physiologic
  functions for desmosomal cadherin isoforms.
  Finally, Dr. Stanley has determined how
  exfoliative toxins produced by staphylococcus
  cause the blisters in bullous impetigo and
  staphylococcal scalded skin syndrome.