Cytokine X

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soluble decoy receptors
Cytokine X
soluble receptor antagonists
SOCS1 - unbridled IFN-? signaling SOCS3 -
negative regulator of IL-6 SOCS5 - negative
regulator of IL-4inhibits TH2 differentiation
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Central Role of TNFa in RA
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THE CHEMOKINE SUPERFAMILY
C-X-C
CXCL1 (Gro? ), CXCL2 (Gro? ), CXCL3 (Gro? ),
CXCL4 (Platelet factor-4), CXCL5 (ENA-78), CXCL6
(GCP-2), CXCL7 (PBP ), CXCL8 (IL-8 ), CXCL9
(Mig), CXCL10 (IP-10), CXCL11 (I-TAC), CXCL12
(SDF-1???), CXCL13 (BCA-1 ), CXCL14 (BRAK ),
CXCL15, CXCL16
C-C
CCL1 (I-309), CCL2 (MCP-1), CCL3 (MIP-1? ), CCL4
(MIP-1?), CCL5 (RANTES), CCL6, CCL7 (MCP-3 ),
CCL8 (MCP-2 ), CCL9 , CCL10, CCL11 (Eotaxin-1),
CCL12, CCL13 (MCP-4 ), CCL14 (HCC-1 ), CCL15
(HCC-2 ), CCL16 (HCC-4 ), CCL17 (TARC), CCL18
(DC-CK-1), CCL19 (MIP-3?), CCL20 (MIP-3?), CCL21
(6Ckine ), CCL22 (MDC), CCL23 (MPIF-1), CCL24
(MPIF-2), CCL25 (TECK), CCL26 (Eotaxin-3 ), CCL27
(Eskine ), CCL28 (MEC)
C
XCL1 (Lymphotactin?), XCL2 (Lymphotactin?)
C-X3-C
CX3CL1 (Fractalkine/Neurotactin)
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Human CCL5 and CXCL8 monomers
CCL5
CXCL8
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In situ hybridizations
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Chemokines and the immune response
Memory T cell
Activation and induction of Th1 T cells in
secondary lymphoid organs
Vasculature
Th1
T cell
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XC Chemokine Receptor XCR1 XCRL1
CXCR Chemokine Receptor CX3CR1 CX3CL1
CC Chemokine Receptors CCR1 CCL3, 5, 7, 8, 13,
14, 15 CCR2 CCL2, 7, 8, 13 CCR3 CCL5, 11,
13 CCR4 CCL17, 22 CCR5 CCL3, 4, 5,
8 CCR6 CCL20 CCR7 CCL19, 20 CCR8 CCL1 CCR9 CCL25 C
CR10 CCL27, CCL28
CXC Chemokine Receptors CXCR1 CXCL1,
8 CXCR2 CXCL1, 2, 3, 4, 5, 6 CXCR3 CXCL9, 10,
11 CXCR4 CXCL12 CXCR5 CXCL13 CXCR6 CXCL16
Viral HCMV-US28 CCL2, 3, 4, 5 HSV-ECRF3 CCL1, 7,
8 KSHV-GPCR CXCL8, CCL10, CXCL12 UL12 CCL2, CLL3,
CCL4 ,CCL5
Duffy Antigen DARC Multiple CXC and CC chemokines