Hypersensitivity

1
Type IV Delayed Hypersensitivity
Antigen Chemical , Bacteria , Virus ,Fungus
Antibody - Complement -
Cells Sensitized
lymphocyte ,
Macrophage ,
PMN Skin test 24-72 hr.
2
Mechanism of Type IV Hypersensitivity
Antigen
Macrophage
Lymphocyte
Sensitized lymphocyte
Lymphokines Killer
cell( ADCC ) Target cells
Cell death ( tissue necrosis )


3
Lymphokines
Chemotactic factor Macrophage migration
inhibition factor ( MIF ) Leukocyte
migration inhibition factor ( LIF )
Blastogenic factor ( BF ) Interleukin II (
TCGF ) Interferon-g Lymphotoxin
etc.
4
Example of Diseases 1.
Tuberculin reaction ( Skin test ) PPD
skin 24-72 h. Induration Redness
2. Contact dermatitis chemical skin
protein T-lymphocyte
lymphokines sen.T-lymphocyte 3.
Allograft rejection tissue A
tissue B 2 set rejection 4.
Insect bite
nd
5
Treatment and Prevention Antigen
avoidance Steroid treatment
- anti-inflammation