Committee Member Training

1
Committee Member Training

• OMB Workshop

2
Overview

• Why were you selected?
• Experts in the field, as determined by your
  peers.
• Ability to critically review methods and
  technical documents.
• Past participation in collaborative studies
• Generous with time, strong-armed by committee
  chair, or gullible.

3
Duties and Responsibilities

• Protocol and Manuscript Review
• SLV Protocols
• Is method technically sound?
• Does protocol follow AOAC recommendations for
  AOAC studies?
• Is the scope and applicability of the method
  sufficiently addressed by the samples chosen for
  the study?
• Will the protocol determine the following
  performance characteristics Accuracy, precision
  (repeatability), linearity/range, LOD/LOQ,
  ruggedness?

4
Duties and Responsibilities

• SLV Manuscripts
• Is method technically sound?
• Was the scope and applicability of the method
  sufficiently address by the samples chosen for
  the study?
• Did the protocol determine the following
  performance characteristics Accuracy, precision
  (repeatability), linearity/range, LOD/LOQ,
  ruggedness?
• Can the method be recommended for a collaborative
  study?

5
Duties and Responsibilities

• Collaborative Study Protocols
• Is method technically sound?
• Does protocol follow AOAC recommendations for
  collaborative studies?
• Is the scope and applicability of the method
  sufficiently address by the samples chosen for
  the study?
• Will the protocol determine the reproducibility
  of the method?

6
Duties and Responsibilities

• Collaborative Study Protocols
• Did the SLV adequately address the other
  performance characteristics of the method?
• If not, does the collaborative study protocol
  address those parameters?
• Is the protocol easy to understand and follow?
• http//www.aoac.org/vmeth/Manual_Part_6.pdf

7
Duties and Responsibilities

• Collaborative Study Manuscript
• Was the protocol followed by the laboratories?
• Does the data support the study directors
  conclusions?

8
Participation on Committees

• Provide advice and guidance to the chair, general
  referee and/or study director.
• Participate in meetings
• Annual meeting
• Phone conferences

9
Participation on Committees

• Vote on Action Items
• Vote on SLV/Collaborative Study Protocols
• Vote on SLV/Collaborative Study manuscripts
• Vote on acceptance of annual committee reports
• Recommendation of method for Official First
  Action
• Recommendation of method for Final Action

10
Participation on Committees

• Most document review and voting can be
  accomplished through AOAC Manuscript Central.
• Recommendations are forwarded to the committee
  chair, who summarizes for Study Director to
  address.
• Study directors can respond to comments and
  revise protocols and manuscripts
• Can lead to several reviews of a document.

11
Participation on Committees

• Members can recommend a topic GR.
• Review the progress of a method through the
  validation process and recommend whether to
  continue/extend a study, modify a study, or
  discontinue a study.

12
Participation on Committees

• Decide on issues such as
• Can a matrix extension be granted for a
  particular method?
• Requires that a method that has already undergone
  a collaborative study process be used as-is for
  another matrix not originally included in the
  study

13
Use of HorRat

• The HorRat is calculated in both SLV and
  collaborative studies.
• Horwitz Ratio
• It is a ratio of the actual (measured) RSD vs.
  the predicted RSD.
• Predicted RSDR 2C-0.15
• C is concentration expressed as a decimal

14
Use of HorRat

• Acceptable values for HorRat are normally
  considered 0.5 2.
• Is often not applicable to indefinite analytes
  (polymers, proteins/enzymes, etc.) and physical
  properties.
• Through a great deal of effort, HorRats lt0.5 can
  sometimes be obtained.
• HorRat is a guideline, and is not an absolute
  criterion. All factors should be taken into
  account when deciding on a methods acceptability.