Organization and Expression of Ig Genes

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Chapter 5 Organization and Expression of Ig Genes
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Fig. 5-1
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From Hozumi and Tonegawa, 1976, PNAS USA 73 3628
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Fig. 5-2
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(human chromosome 22)
(human chromosome 2)
(human chromosome 14)
Fig. 5-3 Gene arrangements
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Fig. 5-4 Kappa gene expression
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Fig. 5-5 H-gene expression
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Fig. 5-6 Recombination signal sequences
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Fig. 5-7 Models of recombination
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Fig. 5-8 Circular DNA isolated from thymocytes
undergoing TCR rearrangement
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Fig. 5-9 Junctional felxibility
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Fig. 5-10 Allelic exclusion (only in B and T
cells)
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Fig. 5-10 Model of allelic exclusion
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Fig. 5-12 Sequence constancy in signal joints
vs. variablility in coding joints
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When ss DNA is generated
Extra nucleotides can also be added
Fig. 5-13 Nucleotide addition during joining
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Fig. 5-14 Somatic variation
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Fig. 5-15 Class switching
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Fig. 5-16 Secreted vs. membrane forms of IgM
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Fig. 5-17 Class switching by alternative
processing
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Fig. 5-18 Secretory pathway
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Fig. 5-19 cis-acting sites
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Fig. 5-20 Ab engineering
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humanized mAb
Fig. 5-21
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Fig. 5-22 Generating Fab libraries
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Fig. 5-23 Grafting miniloci into mice. The
capacity of mice to rearrange was disabled by
knocking out the C? and C? loci
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