Cytoskeleton Hour 11

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Stephen Fish, Ph.D. Marshall University J. C. E.
School of Medicine Fish_at_Marshall.edu
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Note to instructors I use these PowerPoint
slides in cell biology lectures that I give to
first year medical students. Copy the slides, or
just the illustrations into your own teaching
media. We all know that teaching science often
requires compromises and simplification for
specific student populations, or the requirements
of a specific course. Please feel free to offer
suggestions for improvements, corrections, or
additional illustrations. I would be pleased to
hear from anyone who finds my work useful, and am
always willing to make it better. Also, the
images have been compressed to screen resolution
to keep PowerPoint file size down, and I can
provide them at any resolution. Stephen E.
Fish, Ph.D.
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Microtubule Associated Proteins (MAPs)
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Mr. Dynein (click through sequence)
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Motor MAPs

• Dynein tows traffic from plus to minus on
  microtubules toward the centrosome
• Kinesin 1 tows traffic from minus to plus away
  from the centrosome

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Attaching a vesicle to a MAPDoes anybody have a
cold can of ATP for this guy
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Motor MAPs traffic
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Axonal transport on microtubules
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Crawling cell example
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Centrioles
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Cilia detail
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Arrangement of ciliary dynein
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Force applied by ciliary dynein between doublets
causes the cilia to bend
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Ciliary motions are complex
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Sherman says
Dont worry, I ate the exam