Tocotrienols and Cholesterol

1
Tocotrienols and Cholesterol

• Research has clearly proven the ability of
  tocotrienols to lower cholesterol and inhibit
  liver cholesterol synthesis by acting slightly
  different than statins.
• They increase the conversion of Farnesyl (a
  mevalonate derived product which usually goes on
  to make cholesterol) to Farnesol.
• Must be from Annatto source free of tocopherols.
  (Tocopherols block action)
• Should be taken at dinner time or in evening.
  Tocopherols should be taken in morning.

2
Acetyl CoA
HMG-CoA Reductase
Targets HMGCR and inhibits entire IP
Statins
Indirectly inhibits HMGCR by increasing negative
feedback action of farnesol by inhibiting
conversion to farnesyl
Tocotrienol
Geraniol
Isoprenoid Pool (IP)
Farnesyl
squalene
Farnesol
Geranyl Geraniol
Cholesterol
CoQ10
Proteins

• Protein decrease by statin may lead to
• Global Myopathy
• Anemia

• Co-Q10 decrease by statin may lead to
• CHF Cardiomyopathy
• CFS Energy/ATP Deficiency

Source Barrie Tan, PhD Slide by David M. Brady,
ND, CCN