Sex determination 2

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Sex determination 2

• Jonathan Wolfe
• http//www.ucl.ac.uk/ucbhjow/b250/index.html

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mammals
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C. elegans
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Drosophila
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Caenorhabditis elegans
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Chromosome ratios
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Regulation of xol-1
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Caenorhabditis germline
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mRNA regulation
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Sex determination in Drosophila
Inhibition of this splicing pathway. Leads to
positive feedback loop maintaining the setting of
the sxl gene
Inhibition of this splicing prevents translation
of the msl2 protein in females thus preventing
the hyperactivation of the X chromosomes
This activates the more downstream of two splice
acceptor sites thus preventing translation of the
male specific FRU proteins
Doublesex codes for alternative transcription
factors.
Inhibition of this splicing leads to expression
of tra protein in females
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Key interval on 9p
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DMRT1 expression
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Chicken Z Human chr.9
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DMRT1 expression in alligator