Hyperpolarized MRI Imaging

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Hyperpolarized MRIImaging

• By
• Bilal Badr

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Outline

• Hyperpolarization
• 13Carbon Polarization
• Method
• Results
• Discussion
• Conclusion

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Hyperpolarization

• Offer unique advantage in improving SNR
• Goal of Hyperpolarization is to increase nuclear
  spin alignment
• Uses inert gases ( 129Xe , 3He) or 13Carbon
• Utilize low-? for longer T1 relaxation
• Correspond to signal enhancement 10,000

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1H Magnetic Resonance Spectroscopy

• Typically proton used
• Has been found to be useful in observing
  metabolites in vivo
• Disadvantage Most of signal observed comes from
  water and fat which masks signals from more
  interesting metabolites.

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13Carbon Hyperpolarization

• Only 1.1 of carbons in metabolites are 13C
  nuclei
• Enrich specific molecule with 13C
• Applications include
• Angiography
• Cellular metabolism

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13Carbon Hyperpolarization
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13Carbon Hyperpolarization
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13Carbon HyperpolarizationMotivation

• Studied effects of Prohance
• Contains Gadolinium
• Shortens T1 of electron in radical and 13C
• Increases the amount of polarization
• Increases time to reach maximum polarization

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Objective

• Ideal result where polarization time reduced as
  much as possible and T1 is as maximum as possible

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Methods
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Results
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Results
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Results
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Results
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Discussion
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Conclusion

• In general, the best balance for reducing
  polarization time and maintaining good T1 signal
  is
• 1.0 mM of Prohance

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References

• 1) Goldman M., Haukur J., Oskar A. and Magnus K.,
  Hyperpolarization of 13C through order transfer
  science direct, pg (153 157)
• 2) Edward Y., Pratip B. and Brian D., Development
  of Hyperpolarized Contrast Agent California
  Institute of Technology
• 3) Steven R., Devendra B. and Damir B., Chemical
  Kinetics by 13C DNP NMR

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Questions ?