Title: Recent Research Stories Silent Version
1Recent Research Stories (Silent Version)
2Recent Research Stories (Silent Version)
For sound, please feel free to come see me.
Cheers,
Geoff
3Previous Graduates from the Rosenfeld Laboratory
Susan Amara Rouping Chen Bryan Crenshaw Daniel
Drolet Glen Evans Xi He Ola Hermanson Jeff
Holloway Holly Ingraham Kristen Jepsen
Michael Kapiloff Chrissa Kioussi
Peng Li Steve Lipkin Sergio Lira
Professor, Vollum Institute, Investigator,
HHMI Staff Scientist, Celera Genomics Assoc.
Professor, University of Pennsylvania Assoc.
Research Director, NeXagen Inc. Professor, Univ
of Texas, Southwestern, School of Medicine Asst.
Professor, Harvard Medical School Assist.
Professor, Karolinska Institute, Stockholm,
Sweden Staff Scientist, Unigen Pharmaceuticals
Inc. Professor, UC San Francisco Assoc.
Research Scientist, UC San Diego Assist.
Professor, Univ of Oregon, School of
Medicine Assist. Professor, Oregon State
University Professor, The Singapore Institute of
Biology Assist. Professor, UC Irvine, School of
Medicine Adjunct Professor, Mt. Sinai School of
Medicine
3
4Previous Graduates from the Rosenfeld
Laboratory(continued)
Assoc. Research Scientist, UC San Diego Assoc.
Professor, Univ of Oregon, School of
Medicine Assist. Professor, Harvard Medical
School Assist. Professor, University of
Massachusetts Assoc. Project Scientist, UC San
Francisco Assist. Project Scientist, UC San
Diego Assist. Professor, Stanford
University Postdoctoral Fellow, University of
Washington Project Scientist, Illumina Professor
, UC Irvine, School of Medicine Assist.
Professor, University of Massachusetts
Robert McEvilly Geoffrey Murdoch
Anders Näär Franco Rodrigo Marcus
Schonneman Kathleen Scully Mark Sornson
Daniel Szeto Jo Yeakley Marion
Waterman Lan Xu
4
55
6Biochemical Identification of the Nuclear
Receptor Corepressor (N-CoR)
6
7LXXLL Motifs in Coactivator Function
7
8Identification of the Minimal Corepressor/NR
Interaction Motif
8
9Biological Roles of N-CoR (Proliferation/Transform
ation)
9
10N-CoR is Required for NSC Maintenance and
Proliferation
10
11N-CoR is Required to Maintain the Neural Stem
Cell State
11
12Hypothalamic Pituitary Axis
12
1313
1414
15Transient Signaling Gradients and
InducedTranscription Factors in Pituitary
Development
15
16Heritable Defects in Mouse Pituitary Development
16
17Pit-1 Determines Three Anterior Pituitary Cell
Types
17
18Phenotype Variation in Prop-1 Disease Alleles
18
19DNA Binding-independent Functions of Pit-1
Restrict Gonadotrope Gene Expression Out of
Thyrotropes
19
20Three Pit-1 Cell Types Express
DistinctHormone-encoding Gene Targets
20
21Co-crystal Structure of Pit-1 POU Domainson GH
and Prl DNA Response Elements
21
22Combinatorial Recruitment of a Corepressor
Complex inLong-term Active Repression of the GH
Gene
22
23Drosophila sine oculis Mutations
Zipursky et al. Neuron Vol. 12, 977-996 1994
23
24Six6-/- Retinal ProgenitorCells Has Reduced
Proliferation Potential
24
25Six6/Dach2 are Required forPrecise Regulation of
RPC Proliferation
25
26Phenotype of Six1-/- Mice
26
27Phenotype of Six1-/- Mice
27
28The Eya Family are Functional Protein Phosphatases
28
29Model of Eya Phosphatase Actions inSix1/Dach/Eya
Regulation of Organogenesis
29
30Pitx2 / RIEG / Otlx2 / ARP1
30
31Phenotype of Pitx2 Gene-deleted Mice
Visceral and Axial Turning Abnormalities
lung
Right Pulmonary Isomerism
Organ Determination and Proliferation
31
3232
33IL-1b-dependent Export of N-CoR/TAB2/HDAC3
33
34IL-1-dependent KAI1 Gene Induction Based on a
Corepressor/Coactivator Exchange
34
35Models of KAI1 Activation by Inflammation and
Disease
35
36Secretase-dependent Cleavage of APP
36
37APP Interactions with Potential Signalling
Molecules
37
38Presenilin-dependent Generation
ofTranscriptional Coactivators
38
39Potential REST-Regulated Gene Targets
39
40CoREST-dependent Silencing of the rCh39q21-36
Interval
40
41Model of CoREST-dependent Silencingof a
Chromosomal Interval
41
42THE ENDRecent Research
StoriesbyGeoff Rosenfeld