Storyline MD3

1
Storyline MD3

• Medicines that send messages to nerves.

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Designer medicines

• Need a biological understanding of the disease
• Need a lead compound provides a lead / gives
  some clues.

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Adrenal gland
Flight
Fight

• Adrenaline

• Increases blood pressure
• Increases heart rate
• Dilates bronchioles

4

• NORADRENALINE
• NEUROTRANSMITTER
• Fits into and interacts with receptor sites so
• Increases blood pressure
• Increases heart rate
• Dilates bronchioles
• Increases sweating

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Asthma
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(No Transcript)
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• ISOPRENALENE
• AGONIST
• Fits into and interacts with 3 receptor sites so
• Increases blood pressure
• Increases heart rate
• Dilates bronchioles

• NORADRENALINE
• NEUROTRANSMITTER
• Fits into and interacts with receptor sites so
• Increases blood pressure
• Increases heart rate
• Dilates bronchioles
• Increases sweating

Can be dangerous!
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• SALBUTAMOL
• AGONIST
• Selective only fits into one receptor site.
• Dilates bronchioles.
• Also CH2OH slows down breakdown.

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SALMETEROL AGONIST Longer lasting protection
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Do Ass 6 and 7.
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Pharmocore group of atoms which make the
molecule pharmacologically active.
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• The structural fragment which is the
  pharmocophore has
• A shape which precisely fits that of the receptor
  site
• Functional groups which are correctly positioned
  to interact with the receptor site.
• This is called molecular recognition.

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Are they all the same colour?
chromophore
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Solubility?
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Agonists and antagonists
Salbutomol is an agonist behave like a
natural substance from the body.
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Antagonists
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Do Ass 8