Amphetamines

1
Amphetamines

• Intro
• Pharmacology of Amphetamine and Methamphetamine
• Mechanisms
• Effects
• MDMA

2
Amphetamines

• Amphetamine
• l- and d- isomers
• Methamphetamine
• MDMA
• MDA
• MDE

3
Amphetamines

• Naturally occurring compounds
• khat (Catha edulis)
• ephedra (Ephedra vulgaris)

4
Pharmacology of Amph/Meth

• Amphetamine administration
• Oral
• IV
• SC
• Methamphetamine administration
• Oral
• Snorting
• IV
• Smoking
• Runs

5
Mechanisms of Amph/Meth

• Catecholamine systems
• Dopamine
• Reuptake inhibition
• Stimulation of release
• Norephinephrine
• Central and peripheral

6
Effects of Amph/Meth

• Low-dose/Therapeutic effects
• High-dose
• Psychotic Reactions
• Neurotoxicity

7
MDMA

• Psychotherapy
• Recreational use
• raves
• dose/effects

8
MDMA

• Toxic effects
• 5-HT system
• Animals
• Humans
• Neuropsych exam