Auburn University AUBURN, ALABAMA

1
Auburn University AUBURN, ALABAMA
Auburn University at Montgomery
Acute Insulin Responses Following Exercise and
Relationship to Lipid Changes Scott J. Clark1, Jo
shua S. Wooten1, Sofiya Alhassan2, Eric P.
Plaisance2, Victor Ben-Ezra1, Kyle Taylor3, Kyle
D. Biggerstaff1, Peter W Grandjean2, FACSM.
1Texas Womans University, Denton, TX, 2Auburn
University, Auburn, AL, and 3Auburn
University-Montgomery AL. (Sponsor Peter W.
Grandjean, FACSM)

• Participants , continued.
• contraindications to exercise, cardiovascular and
  metabolic disease and drugs known to alter lipid
  metabolism prior to entry into the study. Subject
  baseline characteristics are provided in Table
  1.

• Introduction
• Elevated fasting insulin, a surrogate marker of
  insulin resistance, has been associated with
  dyslipidemia. When clustered together, these
  present as hallmark descriptors of the Metabolic
  Syndrome3. Despres, et al3 has succinctly linked
  insulin resistance to the dyslipidemic profile
  associated with the Metabolic Syndrome (e.g.,
  elevated triglycerides and low HDL). Currently,
  it has been accepted that the primary
  derangements common to the Metabolic Syndrome
  (i.e., insulin resistance and dyslipidemia)
  result from a reduced lipoprotein lipase (LPL)
  sensitivity to insulin which in turn creates a
  metabolic environment of elevated plasma free
  fatty acids (FFA). Chronic elevation of plasma
  FFA may lead to increased tissue triglyceride
  storage (i.e.,lipotoxicity), hepatic and skeletal
  muscle insulin resistance, increased hepatic
  glucose production, and a reduced pancreatic
  ß-cell secretion of insulin.
• Aerobic exercise has been used to reduce the
  risks and complications associated with insulin
  resistance and dyslipidemia1,2,8,9,10,11. In
  fact, a variety of chronic and acute exercise
  protocols manipulating intensity and duration or
  both can improve insulin sensitivity, lower
  triglycerides, and elevate HDL cholesterol1,2,8,9,
  10,11. However, an appropriate dose of exercise
  to positively and concomitantly improve the
  primary variables associated with the Metabolic
  Syndrome (insulin and lipid-lipoproteins) has yet
  to be fully elucidated. In addition, controversy
  exists as to whether postexercise changes in
  lipid variables like triglycerides and insulin
  are even related5.
• Purpose
• To determine the response of fasted insulin and
  glucose concentrations following four consecutive
  days of exercise and to determine if this
  response was related to variables associated with
  serum lipid concentrations.
• Methods
• Participants
• Fifteen middle-aged males with elevated plasma
  cholesterol ( 200 mg/dL) and/or elevated
  triglyceride concentrations ( 200 mg/dL) and who
  did not engage in regular physical (Auburn-Opelika, Alabama area. All volunteers were
  screened for
• Continued