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Auburn University AUBURN, ALABAMA Auburn University at Montgomery Acute Insulin Responses Following Exercise and Relationship to Lipid Changes – PowerPoint PPT presentation

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Title: Auburn University AUBURN, ALABAMA


1
Auburn University AUBURN, ALABAMA Auburn
University at Montgomery
Acute Insulin Responses Following Exercise and
Relationship to Lipid Changes Scott J. Clark1,
Joshua S. Wooten1, Sofiya Alhassan2, Eric P.
Plaisance2, Victor Ben-Ezra1, Kyle Taylor3, Kyle
D. Biggerstaff1, Peter W Grandjean2, FACSM.
1Texas Womans University, Denton, TX, 2Auburn
University, Auburn, AL, and 3Auburn
University-Montgomery AL. (Sponsor Peter W.
Grandjean, FACSM)
  • Participants , continued.
  • contraindications to exercise, cardiovascular and
    metabolic disease and drugs known to alter lipid
    metabolism prior to entry into the study. Subject
    baseline characteristics are provided in Table 1.
  • Introduction
  • Elevated fasting insulin, a surrogate marker of
    insulin resistance, has been associated with
    dyslipidemia. When clustered together, these
    present as hallmark descriptors of the Metabolic
    Syndrome3. Despres, et al3 has succinctly linked
    insulin resistance to the dyslipidemic profile
    associated with the Metabolic Syndrome (e.g.,
    elevated triglycerides and low HDL). Currently,
    it has been accepted that the primary
    derangements common to the Metabolic Syndrome
    (i.e., insulin resistance and dyslipidemia)
    result from a reduced lipoprotein lipase (LPL)
    sensitivity to insulin which in turn creates a
    metabolic environment of elevated plasma free
    fatty acids (FFA). Chronic elevation of plasma
    FFA may lead to increased tissue triglyceride
    storage (i.e.,lipotoxicity), hepatic and skeletal
    muscle insulin resistance, increased hepatic
    glucose production, and a reduced pancreatic
    ß-cell secretion of insulin.
  • Aerobic exercise has been used to reduce the
    risks and complications associated with insulin
    resistance and dyslipidemia1,2,8,9,10,11. In
    fact, a variety of chronic and acute exercise
    protocols manipulating intensity and duration or
    both can improve insulin sensitivity, lower
    triglycerides, and elevate HDL cholesterol1,2,8,9,
    10,11. However, an appropriate dose of exercise
    to positively and concomitantly improve the
    primary variables associated with the Metabolic
    Syndrome (insulin and lipid-lipoproteins) has yet
    to be fully elucidated. In addition, controversy
    exists as to whether postexercise changes in
    lipid variables like triglycerides and insulin
    are even related5.
  • Purpose
  • To determine the response of fasted insulin and
    glucose concentrations following four consecutive
    days of exercise and to determine if this
    response was related to variables associated with
    serum lipid concentrations.
  • Methods
  • Participants
  • Fifteen middle-aged males with elevated plasma
    cholesterol (gt 200 mg/dL) and/or elevated
    triglyceride concentrations (gt 200 mg/dL) and who
    did not engage in regular physical (lt 3 d/wk and
    lt 30 min/bout) were recruited from the
    Auburn-Opelika, Alabama area. All volunteers were
    screened for
  • Continued
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