Persistent ischemia (angina) despite current drug therapy

1
Persistent ischemia (angina) despitecurrent drug
therapy

• Despite use of traditional antianginal agents
  (?-blockers, CCBs, and nitrates), patients
  reported a median of 2 anginal attacks/week
• A significant percentage of patients have
  relative intolerance to full doses of ?-blockers,
  CCBs, and nitrates
• ?-blockers and many CCBs have similar depressive
  effects on BP, HR and/or AV nodal conduction
• Antianginal drugs without these limitations are
  needed

Gibbons RJ et al. ACC/AHA 2002 guidelines.
www.acc.org/clinical/guidelines/stable/stable.pdf
Pepine CJ et al. Am J Cardiol. 199474226-31.