FUNDING OPPORTUNITIES

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FUNDING OPPORTUNITIES

• George S. Johnson, Ph.D.
• February 27, 2004

dtp.nci.nih.gov johnsong_at_exchange.nih.gov
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FUNDING OPPORTUNITIES
NCI provides research support to help meet its
mandate to understand, prevent, and treat
cancer NCI has set a goal to eliminate suffering
and death from cancer by 2015
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FUNDING OPPORTUNITIES
Several support mechanisms are used Grants -
R01, P01, R21, SBIR SPORES, CANCER
CENTER Cooperative Agreements U01, U19 Contracts
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FUNDING OPPORTUNITIES
APPLICATIONS ARE ACCEPTED Unsolicited
through the regular process In response to a
Program Announcement (PA) or Request for
Applications (RFA)
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FUNDING OPPORTUNITIES
HOW DO I LEARN ABOUT SPECIAL INITIATIVES?
PAs and RFAs are listed on the NCI Home
Page (http//www.cancer.gov) All initiatives are
published in the NIH Guide To Grants and
Contracts (http//grants1.nih.gov/grants/guide/ind
ex.html)
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NCI INFORMATION

Subscribe on line to CANCER BULLETIN Go to
cancer.gov - Then to Directors Corner for
instructions
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Useful web sites

• NCI Research Resources (http//resresources.nci.
  nih.gov)
• CSR review of clinical trials
  (http//www.csr.nih.gov/REVIEW/clin_research_appls
  .htm)
• Video of Mock Grant Review
• (http//www.csr.nih.gov/Video/Video.asp)

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FUNDING OPPORTUNITIES

• Something new to watch
• NIH ROADMAPS
• http//nihroadmap.nih.gov
• Recent Example
• RFA-RM-04-012
• High Throughput Molecular
• Screening Assay Development

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RESOURCES
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FUNDING OPPORTUNITIES

• The Grants and Contracts Operations Branch,
• within the DTP, supports grants focused on
• New drug discovery and development
• Mechanism of drug action
• - New molecular target identification
• Model development
• Technology including combinatorial
• chemistry

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FUNDING OPPORTUNITIES

• National Cooperative Drug Discovery Groups
• (NCDDG)
• Started in 1983
• Prototype example of academic, industry,
• government partnering for successful
• drug discovery
• Various scientific disciplines work together
• with common goal
• Government contract resources and industrial
• support

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FUNDING OPPORTUNITIES

• NCDDG SUCCESSES
• 11 agents into clinical trial
• 3 NDAs
• Topotecan
• Gliadel
• DAB389IL2 (ONTAK)

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FUNDING OPPORTUNITIES

• NCDDG
• RFA recently reissued and published
  
  in NIH Guide
• RFA-CA-05-001
• Receipt date is May 19, 2004

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Academic Public Private Partnership Program (AP4)

• To stimulate cancer intervention discovery and
  development at academic/non-profit centers in
  partnership with other academics, industry,
  non-profits and government.
• To incorporate the latest technologies to find
  novel, mechanistically targeted drugs and other
  intervention strategies for underserved diseases
• To combine the necessary expertise to reduce the
  time required to translate novel interventions to
  the clinic.
• RFA-CA-04-005

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AP4 Primary Features

• Academic or Non-profit Director
• Each Center can have many contributing partners
  - academics, pharma, biotechs, non-profits,
  govts
• Most research is carried out at the Center
• All partners agree to a membership agreement
• Steering Committee (SC) - AP4 Director, partners
  and NCI SC determines to Center projects
• Focus is preclinical discovery early
  development of interventions with access to NCI
  development and clinical resources

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AP4

• Solicitation for Planning Grant is closed
• Only Planning Grant awardees can apply
• Awardees will be listed on DTP web site
• Others may possibly join AP4 group if approved by
  Steering Committee and agree to terms of award

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FUNDING OPPORTUNITIES
SBIR Set-aside program for small businesses to
engage in federal RD with commercialization
potential.
STTR Set-aside program to facilitate
RD between small businesses and U.S.
research institutions with commercialization
potential.
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FUNDING OPPORTUNITIES
FLAIR
Flexible System to Advance Innovative Research
for Cancer Drug Discovery by Small Businesses
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FUNDING OPPORTUNITIES
FLAIR
PA-01-091
Established as part of SBIR/STTR programs to
support innovative drug discovery - Allows
for larger budget and number of years Phase
I (300,000 vs 100,00 per year) Phase II
(750,000 per year vs 650,000 for two years)
- Encourages development of innovative
therapies through proof of principle in
clinical trial
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FUNDING OPPORTUNITIES
FLAIR
Initiated in 1998 5 grant rounds 132
applications received 47 funded
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FUNDING OPPORTUNITIES
FLAIR
Supports wide range of topics - drug and
vaccine discovery - biologicals - new
delivery approaches - gene therapy Promotes a
more realistic approach to support cancer
therapy in SBIR program
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FUNDING OPPORTUNITIES
FUTURE DIRECTIONS?

• -Team Approach to
• problem solving
• - Translational research
• Partnerships
• 2015 goal
• - Budgets

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FUNDING OPPORTUNITES
How does one learn of new initiatives? - Read
NCI Homepage and Directors Corner -
Contact Program Directors - Check NIH Guide to
Grants and Contracts every week