The Histopathology of IPF

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The Histopathology of IPF

• UIP is the histologic lesion essential for IPF
  diagnosis
• Cardinal features
• Temporal heterogeneity
• Dense fibrosis?normal lung
• Predilection for peripheral (subpleural) and
  basilar region
• Fibroblastic foci (aggregates of proliferating
  fibroblasts and myofibroblasts)
• Microscopic honeycomb cysts

ATS/ERS Consensus Statement. Am J Respir Crit
Care Med. 2000161646-664. Kaminski N, et al.
Am J Respir Cell Mol Biol. 200329S1-S105.