Research Services presents

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Research Servicespresents
Study Section TrendsCareer Development
Awards Moderator William G. New, Associate Dean
for Research, SOM
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Study Section Trends

• Agenda
• Welcome, Announcements and Introductions
• Panelists Presentations
• Discussion

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Study Section Trends

• Problem
• Early awards often launch research careers
• New investigators usually do not know what their
  applications should include or emphasize

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Study Section Trends

• Observations
• Review committees tend to look differently on
  career development awards than on research awards
• Individual
• Career path
• Mentors

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Study Section Trends

• Panelists
• Mabel Caban, M.D.
• Assistant Professor, Department of Orthopaedic
  Surgery and Rehabilitation
• James S. Goodwin, M.D.
• Professor of Medicine and Director of Sealy
  Center on Aging
• Claire E. Hulsebosch, Ph.D.
• Vice-Chair and Professor, Neuroscience and Cell
  Biology
• Slobodan, Bobo Paessler, D.V.M., Ph.D.
• Assistant Professor, Department of Pathology
• Scott Weaver, Ph.D.
• Vice-Chair for Research and Professor, Department
  of Pathology and Director for Tropical and
  Emerging Diseases, Center for Biodefense and
  Emerging Infectious Diseases

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National Institute for Neurological Disorders and
Stroke (NINDS) K Awards What a Reviewer Requires

• Claire E. Hulsebosch, Ph.D.
• Director, Mission Connect
• Vice Chair and Professor, Neuroscience and Cell
  Biology

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National Institute for Neurological Disorders and
Stroke (NINDS) K Awards

• The NINDS supports a broad spectrum of K awards,
  including both mentored and independent awards.
• Described in the NINDS training and career
  development website http//www.ninds.nih.gov/fund
  ing/research training.htm
• Awards include the K01, K02, K08, K22, K23, K24
  and K25.

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NINDS K Awards

• The major objective is to support the career
  development of clinician scientists (must have MD
  or equivalent AND board certified i.e., able
  to treat patients in the US).
• This includes research experience and
  grantsmanship.

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NINDS K22, K24 and K25 Awards

• K22 Enables outstanding individuals to obtain a
  research training experience in the NINDS
  Division of Intramural Research and facilitate
  successful transition to an extramural
  environment as independent researchers. 2-3 years
  in a NINDS intramural laboratory followed by 2-3
  years of support for an independent research
  project in an extramural institution.
• K24 Midcareer Investigator Award in
  Patient-Oriented Research
• K25 Mentored Quantitative Research Career
  Development Award

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NINDS K01 Awards

• For investigators at the postdoctoral or early
  faculty development stage to focus their efforts
  on translational research in neurological
  disorders.
• To promote more extensive interaction among basic
  and clinical researchers.
• To accelerate the development of interventions
  and effective treatments that will improve the
  quality of life of persons with neurological
  disorders.

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3 Types of NINDS K01 Awards

• "NINDS Mentored Research Scientist Development
  Awards in Translational Research"
  (http//grants.nih.gov/grants/guide/pa-files/PAR-0
  2-140.html).
• "Career Development Award for Minority Scholars
  in Neuroscience" (http//grants.nih.gov/grants/gui
  de/pa-files/PAR-02-106.html).
• Re-Entry Into the Neurological Sciences Program
  (http//www.ninds.nih.gov/funding/postdoc.htmk01)
  .

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NINDS K01 Awards

• Factors of PI Considered in Review
• Demonstrated the potential for highly productive
  independent research in the period after the
  doctorate.
• The candidate must identify mentor(s) with
  extensive basic and/or clinical research
  experience.
• Candidates must be willing to spend a minimum of
  75 percent of full-time professional effort
  conducting research and research career
  development during the entire award period.
• The candidate must clearly describe the need for
  intensive research supervision for a period
  lasting 3-5 years, leading to research
  independence.

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NINDS K08 and K23 Awards

• Both are MENTORED awards (Junior PI with Senior
  Co-I who has successful NIH track record) BUT the
  NINDS encourages applicant institutions to
  demonstrate strong commitment toward the academic
  independence of candidates for these Awards (read
  here MUST HAVE A FACULTY APPOINTMENT AND
  PROTECTED TIME).
• The level of institutional commitment IS A MAJOR
  FACTOR.
• 3) K08 is translatable research, K23 is patient
  oriented research.

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NINDS K08 and K23 Awards

• Scientific Factors Considered in Review
• Junior PI must have publication record (4 or 5)
  and evidence of success in research (small
  grants).
• Senior PIs must be outstanding in terms of
  productivity and grantsmanship recognized leader
  in the research area and have a track record of
  success in training independent investigators .
• Scientific project must be feasible, translatable
  and be deemed a valuable training experience.
• Ability of scientific independence of junior PI
  must be addressed.
• All successful mentored awards have some course
  work included as part of training experience.

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NINDS K08 and K23 Awards

• Institutional Factors Considered in Review
• Type of institutional appointment.
• Sufficiency of funds available to carry out the
  proposed research.
• Sufficiency of dedicated space for the candidate.
• Sufficiency of protected time for the candidate
  (75 or so effort).
• Other resources available to the candidate.

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NINDS K02 Awards

• Follows a K08 award to support the continued
  career development of independent
  clinician-scientists for an additional 5 years
  (to obtain an R01 or equivalent).
• The award provides both Salary and Research costs
  for the first 3 years, and continued salary
  support for years 4 and 5, contingent on receipt
  of an R01 or equivalent award.
• NINDS considers an R01-equivalent grant to be an
  independent, peer-reviewed, multi-year award with
  the K02 awardee as PI, and the total award must
  be for a minimum of 75,000 per year for 3 years
  or 100,000 per year for 2 years.

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Thank you for your attention.

• Claire E. Hulsebosch, Ph.D.
• Director, Mission Connect
• Vice Chair and Professor, Neuroscience and Cell
  Biology

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Mentored Clinical Scientist Research Career
Development Award (K08)

• Mabel Caban, M.D.
• Dept. Orthopedic Surgery Rehabilitation-SOM
• Division Rehabilitation Science-SAH
• National Cancer Institute K08 in 2005 for
  Effects of Disability on the Diagnosis of Breast
  Cancer

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Choose a Mentor

• Single most important decision
• Chemistry
• Productivity
• Active grant writers publishing
• Resources track record of training others
• Someone with whom you have published
• Ask if he/she will support your application

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Participating Organizations

• Check NIH website
• http//grants.nih.gov/grants/guide/pa-files/pa-06-
  512.html
• Take advantage of your profile
• Seed funding (search InfoEd)
• Institution, foundation or national academies
• Read the Program Announcement
• Contact the Institute check your eligibility
• Contact department head UTMB directors

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Decision Making

• 75 research
• 25 clinical

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The Process

• Request funded K awards from mentor
• Writing the grant
• Mentor
• Environment institutional support resources
• Candidate
• Develop idea from work as research fellow
• Specific Aims and Model
• Significance innovative, timely, important
• Responsible conduct of research
• Sound methodology

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Timeline
Apply CIRWH Start K award Draft to
Submit Summary Program NOGA Seed Grant
award Application Program Director
K08 Statement Contact 5/2003 8/2003
8/2003 1/2004
2/2004 8/2004 8/2004 10/2005
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The Process

• Start now
• Meet with mentor and provide drafts q. week
• Use editors
• UTMB is the right place
• You can do it

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Two Slides Worth of Advice on K Awards

• James S. Goodwin, M.D.
• George Cynthia Mitchell Distinguished Chair in
  Geriatric Medicine
• Director, Sealy Center on Aging

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Writing a Career Development Proposal General
Advice

• Thinking straight is immensely difficult for
  everyone. Do not handicap yourself by using
  complex, florid language.
• An NIH proposal is like a long letter to two or
  three people the only people who will ever read
  it. Your job is to make it easy for those two or
  three individuals to understand your proposal.
• For example
• Avoid abbreviations
• Use frequent summaries
• Use headings for everything
• Construct lots of diagrams, figures, tables,
  lists and white space
• Schedule your efforts so that you produce a
  complete first draft at least four weeks prior to
  submission. Send it out for review.

Sealy
Center on Aging
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Writing a Career Development Proposal Specific
Advice

• The major product of a K-Award is the individual,
  not the science.
• Thus, it is key to
• Provide a credible career development plan. This
  cannot be an afterthought.
• Think long and hard about what you want to be
  doing in five years really. Then communicate
  that in a coherent manner and make sure the rest
  of the proposal is consistent with that vision.

Sealy
Center on Aging
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Thoughts on a K08 Award Application

• Slobodan, Bobo Paessler, D.V.M., Ph.D.
• Assistant Professor, Department of Pathology
• National Institute of Allergy and Infectious
• Diseases K08 in 2004 for VEE Pathogenesis and
  Vaccine Development

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Characteristics of a Strong Career Development
Grant Mentor, Basic Sciences

• Scott Weaver, Ph.D.
• Vice-Chair for Research and Professor,
• Department of Pathology
• Director for Tropical and Emerging Diseases,
  Center for Biodefense and Emerging Infectious
  Diseases

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Characteristics of a Strong Career Development
Grant Mentor, Basic Sciences

• History of strong, stable grant funding,
  preferably including NIH R01s, and preferably
  extending through the proposed training period.
• Strong publication record, preferably including
  collaborative, interdisciplinary publications
  that have involved past trainees.
• History of mentoring trainees who have been
  productive and remained in science, ideally in
  academic biomedical research as faculty.
• Ability to provide trainee with a tailored set of
  training activities to meet their career goals.

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Research Services

• Thank you.
• Questions from the audience.