????DNA(????????)???????????A,G,C,T???4????????????????????????????????2??0?1?????????????????????????????????

1
?11? ??????
2
????DNA(????????)???????????A,G,C,T???4??????????
??????????????????????2??0?1??????????????????????
??????????? ?????????????????????????????60??????
???????????????????????????????????????1??????????
?????????? ????????????????????(??)???????(??????)
???????
3
DNA???????????????
???? G-C?3? A-T?2?
??????. ??????????, ??, 1997, 2p.
4
(No Transcript)
5
????????????????????????? ????????????????????????
?

?? P.Poulsen et al. Diabetologia 44537-543
(2001)
6
(No Transcript)
7
(No Transcript)
8
???????????????????????????????????????????????
9
????????????????

• 1.???? ???????????? ßARs?UCPs
• 2. ????? ??1?10g?????? AGT?TT?
• 3. ???????? ????????? ALDH2?2?
• 4.????? ???????500ml ??lactase??
• 5.???????? ?????? SerotoninT?SS?
• 6.?????????????????????? MTHFR?TT?
• 7.???????????????? SOCS2???
• 8.???????????????????CYP??
• 9. ?????????????? ????????????

10
DNA??RNA???????
??????. ??????????, ??, 1997, 16p.
11
DNA???????
??????. ??????????, ??, 1997, 20p.
12
??????????????

DNA?CpG?????????????
???
???????????? (epigenetics)
???????????????(bioinformatics)
????????
?????? ????????
????. ???????. ?????????, 2006, 163p.
13
??????????????????????
???????????????
??????????????????
?????????????????????
14
(No Transcript)
15
(No Transcript)
16
???????ß3????????????
?????? ???????? 127?
??????? 175?
(???? 21)
(???? 50)
Plt0.01
NS
R/W
W/W
R/W
W/W
????????(?????)
17
?????????????????????????????????????????

• ?ß3?????????? (ß3AR)
• Trp64Arg
• ? ??????2(UCP2)
• 45bp insertion/deletion
• ? ??????3
• (UCP3)
• C-55T

??????????? ????????
18
???????????????????????? ????????????????????????
????,??????, Available from lthttp//metab.kuhp.kyo
to-u.ac.jp/IKAI/report/no8.htmlgt, (accessed
2007-12-11)
19
(No Transcript)
20
??????????????????????????????
SOCS2(supressor of cytokine signaling 2) ?????
21
???????????????????????3?????????31???????
???????????????
???? ?? ??? ??? ???
22
(No Transcript)
23
???????????????????
(??)
(Ishikawa, Hypertension 2001)
(Ishikawa, Am J Hypertens 1998)
(Tsujita, Hypertens Res 2001)
(Ishikawa, Am J Hypertens 2000)
24
????????????T786C??????????11.7g/??????????????
??45?????281? 17??????????TC/CC?
Miyaki. K. et al. Salt Intake Affects the
Relation Between Hypertension and the T-786C
Polymorphism in the Endothelial Nitric Oxide
Synthase Gene Am J. Hypertension. 18(12), 2005,
1556-62
25
????3????????????? ????????????????
??????()
26
???(BMI)?4??????????????????????????????????????
ß3AR
UCP2
(?/m2)
(?/m2)
(?/m2)
(?/m2)
ns
ns
????(n91)
????(n56)
????(n105)
????(n42)
(?/m2)
(?/m2)
(?/m2)
(?/m2)
UCP3
FABP2
ns
ns
????(n83)
????(n64)
????(n59)
????(n86)
???
???
???
???vs????Wilcoxon????????? ????vs?????Mann-Whitney
?U??
27

??????2???/?????????????????????????
????????
????
(mg/dl)
(mg/dl)
p0.0007
plt0.0075
p0.0417
plt0.0001
p0.0005
11548
24153
plt0.0001
plt0.0001
9742
22546
21036
8025
7525
19736
??? ???
??? ???
??? ???
??? ???
??? (n94)
???? (n34)
??? (n105)
???? (n42)
28
??????????????????
During this 15 years Heart diseases x
5.1 Diabetes x 7.5 Cancer x 1.3
Thailand Health Profile 2000
29
??????????????????????????????????????
Okinawa (n100)
30
?????????????????????
A
???????????????
?????????????????????
????
? ?
B
31
????????????????????????2006?3?12??? ???????????

• ?DNA????????1????????????55???????????????
• ?????????????????70????1????29?????????????????
  ?????????????????????????????66??????????????????
  ?????
• 05?11??????????4?????

32
73???????????
??????????????????????????(2006?2?)
33
????????????????????????????????????????????????

• ??????????????????????????
• ??????ß3???????????Arg???1?200kcal????????????1kca
  l1??1??36??/???
• ????????????????????????
• ??????????????????????????????????????????????????
  ?????
• ????????????????????????????
• ??????????????????????????????????????????????????
  ?
• ????????????????????????????

34
?????(????)????(????) ?????
???????????????????????????
?????????????(????) ?????
???????????????????????????
???????????
?????????????????? ?????
(????????)
35
???????????????????????
(??ha)
?? ?? ??? ??????
36
(No Transcript)