RECRUITMENT TALK

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RECRUITMENT TALK

• Remember
• There are few positions and many candidates
• 200-500 candidates for any tenure track faculty
  position
• 10 qualified people for each position
• I receive 30-50 unsolicited requests per month
• Step 1 Getting the Interview
• CV and personal statement
• Review standard University CV formats
• I do not care what you think your skills are
• I want to know what you have produced
• I want to know what your training is
• I will respond better to what I am used to
  seeing

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RECRUITMENT TALK

• What am I looking for in a trainee candidate
• What am I looking for in a faculty candidate

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RECRUITMENT TALK

• You only get one chance to make a first
  impression
• Arrive early
• Dress Professionally
• Males Tie and Jacket
• Females Consider a suit
• At least a dress or skirt.
• Live with your clothes. Do not fidget
• I am looking for a professional colleague
• Slides must be clear, single format

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RECRUITMENT TALK

• What am I looking for in a trainee candidate
• Career goals
• What do you want to do in 5 years
• How will you get there
• What are your strengths and weaknesses
• Are you driven to succeed
• Talk
• Organization
• Thought process
• Much more important than the data
• Handling questions more important than the talk
• NEVER EVER INTERRUPT
• I am making a commitment to your career
• Will you be successful
• Are you teachable
• Do you want to learn or do you already know it
  all

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RECRUITMENT TALK

• What am I looking for in a Faculty Candidate
• Someone I trust
• Represent me in meetings
• Not cause problems in and for the department
• A team player and collaborator Team sports
• There is no I in a talk
• Someone I want to work with, go to dinner with,
  go to meetings with
• Someone who will make me better or my life easier
• Will they teach classes well
• Will they get grants
• Are they going to be a good teacher
• Are they intellectually curious Will they listen
  to my questions. Will they review my grant and
  help me
• Have they asked their supervisor about the
  project and what they can take with them

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RECRUITMENT TALK

• There are many candidates.
• Recruitment is occasional.
• For students, we are looking at being
• together for 4-6 years, PDFs 3-4 years, faculty a
  lifetime.
• Divorce (termination) is painful
• Estimated cost of a wrong faculty rectruitment
  750K
• There are many ways to make a mistake, few to
  make a good first impression
• Better to recruit no one than the wrong one

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RECRUITMENT TALK

• 3 PARTS
• Scientific Presentation
• One on one interviews
• Dinner

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RECRUITMENT TALK

• PREPARATION FOR THE TRIP
• Its not all about the talk
• DO YOUR HOMEWORK.
• Institution
• If you are going to Duke, know about the
  basketball team
• If you are going to UT, know about the football
  team
• Texas A and M, know what an Aggie is.
• People
• Study your agenda
• Know who you are meeting.
• Review online.
• What is their latest paper. Know their history
• Many people have websites or lab websites
• IL2, LAKs and TILs
• Know who you are going to dinner with

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RECRUITMENT TALK

• TALK
• Prepare practice and give it to as many people
  who will listen
• Have people look at slides
• Spelling errors, too busy
• Use SpellCheck
• PDF presentation is safest approach
• Do not tell jokes or try to be funny.
• You can have an amusing slide
• NO motion slides unless absolutely necessary
• If possible overlay slides if motion needed

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RECRUITMENT TALK

• THE TALK
• Expect to be nervous
• Where to stand
• Your slides can be crutches.
• Do not read your slides but they are there if
  you need them
• Speak slowly and clearly
• If you get lost, do not panic. Take a deep breath
  and start again.
• Make clear transitions. A few second gap is OK.
• Tell one or maybe two stories well, not many.
• Do not assume anyone has read your favorite
  papers including your own.

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RECRUITMENT TALK

• THE TALK
• Every slide should have a message and a reason
  to be in the talk
• Tell a story. The talk should have a beginning
  middle and end.
• Place the topic in context
• Big picture
• Logic flow A set of slides showing what you will
  present Fade in an out.
• Results
• Conclusion
• Appropriate amount of time
• 45 minutes

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RECRUITMENT TALK

• THE TALK
• Are you logical
• Are you careful
• Acknowledge anyone who did the work on the slide
• Introduction
• Put the topic in context
• Enough background so people understand the
  question
• What is the question
• Why is this important

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RECRUITMENT TALK

• The four slide cassette
• Introduction slide
• Set the question
• Present a model describing the question
• A picture is worth a thousand words!
• Method slide
• What was done and why
• Explain the approach and why
• Data slide
• Make a new slide for the talk with key points
  only
• NOT from your paper
• Controls are critical
• Are you careful.
• Conclusion/transition slide
• What does the data show you
• Go back to your model
• Present a revised model slide
• What is the next question
• Set the next cassette

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RECRUITMENT TALK

• THE END
• What have you learned
• What are the next questions
• One and maybe two slides
• What would the title of your grant application be
• What is the model
• What are the aims

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RECRUITMENT TALK

• THE DREADED DINNER
• Do not drink AT ALL
• It is too easy to sip too many times.
• If they order you a drink or a glass of wine pick
  it up put it to your lips occasionally and do not
  drink
• Think about what you order
• Order a salad
• Main course should be easy to eat
• Skip desert
• Only order coffee after others
• DO NOT order spaghetti.
• Do not discuss politics or religion unless asked
  and then say little and try to change the topic
• Nobody cares about how they do things at home
• You must participate
• People like to talk about themselves
• Where are they from. How did they get to the
  institution. Why did they come
• Try to sit next to someone you know or the
  recruit leader
• The Dinner is not a time to ask contentious
  questions

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THE OFFER

• Review carefully
• Ask questions but not too many
• No one wants to work with someone who is a pain
• Your best chance to negotiate is up front
• No one wants to work with someone who is not
  excited about the job. Too much negotiation will
  lose the job
• Produce and renegotiate
• Produce and move elsewhere

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WHAT GOES AROUND COMES AROUND MULTIPLE GENOMIC
AMPLICONS TARGET VESICLE RECYCLING AND
BIOENERGETICS Joe Gray William Muller Jim Norman
Gordon B. Mills Department of Systems Biology
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15 years of fishing in the genome pool
FISHING CAN WORK IF YOU USE THE RIGHT BAIT
JOE GRAY LBL AND FRIEND
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Early Stage Breast Cancer Resource (2408 tumors
Stage 1,2 paraffin n 971 MIP arrays) Decision
tree analysis










Melissa Bondy, Patricia Thompson, Spyros
Tsavichidis
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GENOMIC ABERRATIONS TARGET ENDOCYTOSIS AND
POLARITY
PKCi PIK3CA MDS1 EVI1 Mir
PVT1 Myc
ERBB2 Grb7
Rab11FIP1 RCP
Cyclin D1
ZNF217
Rab25
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RAB11FIPS AND RAB11 FAMILY MEMBERS ARE
OVEREXPRESSED IN CANCER
Bittner Oncomine
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RAB25 AND RCP COOPERATE IN LUMINAL B TUMORS
Rab25 is expressed in ER positive and HER2
positive, low in basal, absent in Claudin low
Ju-Seog Lee Fan Zhang
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RAB25 AND RCP COOPERATE IN LUMINAL B TUMORS
Ju-Seog Lee Fan Zhang
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RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE
PLEIOMORPHIC FUNCTIONS
RECYCLING
Specific Signaling Complexes
DECISION
DEGRADATION
Jim Norman
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RAB25 AND RCP REGULATE MOTILITY AND INVASION
THROUGH SPATIALLY RESTRICTED RECYCLING AND
LOCALIZED SIGNALING
Jim Norman
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Rab25 drives extension of invasive pseudopods

• Rab25/a5b1 compartment is located near the tip

GFP-a5 integrin Cherry-Rab25
N
Patrick Caswell/Heather Spence
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RAB25 INTERACTS WITH EGFR
Roshan Agarwal Kwai Wa Cheng
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RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE
PLEIOMORPHIC FUNCTIONS
RECYCLING
Specific Signaling Complexes
DECISION
RAB25 includes a sequence change found in mutant
RAS and should be GTP bound Dominant active Rab11
family member Rab25 preferentially binds RCP and
integrins in presence of Rab11
DEGRADATION
RAB11 GDP
RAB25 GTP
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RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE
PLEIOMORPHIC FUNCTIONS
RECYCLING
Specific Signaling Complexes
DECISION
RAS
AKT
Raf
Mek
GSK3
TGFb signaling
DEGRADATION
MAPK
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RAB25 AND RCP EXIST AS A HETEROTETRAMERIC
COMPLEX Greg Verdine Stapled peptides
Rab25
Rab25
RCP
RCP
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RAB25 INTERACTION NET ReMTH, Yeast two hybrid,
ip Mass Spec, Lumiere, Literature, STRING
GLUT1
Actin capping protein
Integrina5 b1
RCP
EGFR
AKT
TGFbR1
Igor Jurisica, Roshan Agarwal, Zhiyong Ding, Kwai
Wa Cheng, Jim Norman
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RAB25 TRANSCRIPTOME IMPLICATES RAB25 IN
BIOENERGETICS
53-gene signature
Roshan Agarwal Kwai Wa Cheng
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GLYCOGEN IS A POTENTIAL ENERGY SOURCE
AKT
GSK3
Rab 25
GPI
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ATP and GLYCOGEN ARE INCREASED BY RAB25
Kwai Wa Cheng
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GLYCOGEN STORES CONTRIBUTE TO THE ABILITY OF
RAB25 TO MAINTAIN ATP LEVELS
Rab 25
Roshan Agarwal Kwai Wa Cheng
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Mechanisms of action of Rab25
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COLLABORATORS
MILLS LAB Joe Gray LBL Rab25 Kwai Wa
Cheng Bill Muller McGill Canada Roshan
Agarwal Sofie Claerhout Jim Norman
Beatson Scotland Yiling Lu Qinghua Yu Igor
Jurisica University of Toronto Shuangxing
Yu Shreya Mitra ReMTH Zhiyong Ding Robert
Bast MD Anderson Bioenergetics Ju Seog Lee MD
Anderson Jae Ho Cheong Jiyong
Liang RPPA/PI3K/Patient samples outcomes Yiling
Lu Bryan Hennessy Ana Gonzalez Mark Carey Fan
Zhang
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COLLABORATORS
MDACC San Francisco Joe Gray Wenlin Kuo Ju-Seog
Lee Prahlad Ram Boston Joan Brugge Levi
Garraway Gabor Balazsi John Albeck Yoko
Irie Shiaw-Yih Phoebus Lin St. Louis Chuck
Perou Georg Halder Vanderbilt Carlos Arteaga
Gabriel Hortobagyi UBC Sam Aparicio David
Huntsman Funda Meric-Bernstam Baylor Zhou
Sunny Songyang Robert Bast Cheryl Walker
Powel Brown Adrian Lee Jenny
Chang Steve Kornblau Holland Rene Bernards
Melissa Bondy John Heymach Norway Anne-Lise
Boerresen-Dale Michael Andreeff Therese
Sorlie Eric Jonasch Spain Jose Baselga Ana
Lluch Tissue Bank Ayesegul
Sahin Toronto Patricia Shaw Heather
Begley Karen Lu Ignacio Wistuba San Francisco
Karen Smith McCune Rosemarie Schmandt
Bioinformatics Toronto Igor
Jurisica Kevin Coombes John Weinstein San
Francisco Paul Spellman, William Gibb Jonas
Almeida Keith Baggerly Sach Murkherjee Mandri
Obeyesekere GSK/Semafore/Abbott/Exelixis/Keryx
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