Vesicular Transport III

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Vesicular Transport III
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N-linked glycosylation because sugar is added to
N of asparagine.
original precursor oligosaccharide added to most
proteins in the ER
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Oligosaccharide chains are processed in the Golgi
complex
common core
high-mannose
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Vesicular transport model
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Cisternal Maturation Model
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Lysosome interior is different from cytosol
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Detection of acid phosphatase in lysosomesSmall
spheres may be vesicles delivering the enzyme
from the Golgi Apparatus
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Structure of oligosaccharide that directs
lysosome enzyme to the lysosome
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3 pathways to degradation in the lysosome
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Autophagosome with mitochondrion and peroxisome
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3 possible fates of receptor proteins in an
epithelial cell
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Phagocyte ingesting chemically altered red blood
cells
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A neutrophil phagocytosing a bacterium
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Formation of clathrin coated membrane from the
plasma membrane
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Formation of clathrin coated membrane from the
plasma membrane
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Caveolae in the plasma membrane of a fibroblast
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Caveolae in the plasma membrane of a fibroblast
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Low Density Lipoprotein particle transports
cholesterol in the blood
1500 cholesterol molecules esterified to long
chain fatty acids in one particle
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Normal LDL receptors facilitate transport of
cholesteryl esters in clathrin coated vesicles
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Defective LDL receptor protein causes high levels
of blood cholesterol and heart disease
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cholesterol is released in lysosome
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opiod receptor green transferin red