Intra Uterine Insemination - IUI

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Intra Uterine Insemination - IUI
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What Is IUI?

• Procedure to treat infertility by
• Ovaries Stimulated to produce more eggs
• Seminal fluid washed in artificial media and
  introduced into the uterus
• Sperms swims towards the egg for fertilization to
  take place
• Entire procedure takes 15-20 minutes

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Indications of Intra Uterine Insemination

• 1. Infertility Due to Abnormal Semen
• Can be either due to abnormal sperm shape,
  motility and viability. IUI helps to separate the
  normal sperms from abnormal sperms thus achieving
  fertilization.

2. Cervical Factors Abnormal position of the
cervix preventing sperm travel to the egg. Thick
cervical secretion during ovulation thus
preventing sperm ascent to the uterus and to the
egg.
3. Ovulation Problems
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• 4. Semen Allergy
• Some woman are allergic to the protein in the
  semen of their husband which causes discomfort
  after intercourse so most couple prevent
  intercourse thus preventing pregnancy.

5. Unexplained Infertility There are many
unexplained reasons for infertility for which the
only treatment solution is IUI.
6. Antisperm Antibodies 7. Erection and
Ejaculation disorder 8. Mild Endometriosis
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The cases in which Intra Uterine Insemination is
ineffective

• Blocked or damaged fallopian tubes.

• Ovarian failure.

• Severe seminal fluid abnormality

• Severe endometriosis

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Preparation for Intra Uterine Insemination -
Artificial Insemination
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Intra Uterine Insemination Procedure
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Success rate of Intra Uterine Insemination - IUI

• The pregnancy rate of IUI is 10-20 and it
  depends on the age of the wife, her health
  situation, and also on the number of motile sperm
  that is used in each cycle, and the pregnancy
  rate in 2 IUI cycles using 5 million sperm is
  more than the pregnancy rate in 1 IUI cycle using
  10 million sperm.

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• For couples of unexplained infertility, trying
  for 2 years, female age under 35, and normal
  sperm, the success rate is as follow

• 10 chance per month using clomid, and IUI for up
  to 3 cycles

• 15-20 chance per month using injection by FSH
  medication, and IUI for up to 3 cycles.

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Risks of Intra Uterine Insemination - IUI

• Rarely, IUI may cause infection in the uterus and
  tubes, from bacterial contamination that
  originate either from semen sample, or
  contamination of sterile catheter in the vaginal
  or cervical area during the procedure. Careful
  cleaning of the cervix and cautious technique
  alleviate this and make it a rarity.

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Commonly Asked Questions

• How many times can the IUI be done?The IUI is
  usually done twice during the treatment cycle,
  and it has been proved that doing the IUI twice
  increases the pregnancy rate because it decreases
  the loss of the fertility period during the
  ovulation, but there was a study that was done
  comparing the pregnancy rate after IUI on one
  time, or two times, and found no difference.

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• After the Intra Uterine Insemination any life
  style changes is required?

• Usually, the IUI procedure takes from 15-20
  minutes. The patient is then asked to lie down on
  her back for a period of time

• The patient can continue her normal life, and
  passage of a small amount of blood in 1-2 days
  after IUI is normal

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• When to expect the Intra Uterine Insemination
  Results?

Pregnancy test should not be done before 2 weeks
have past since the IUI. Doing it before this may
cause false negative result (which means that the
patient is pregnant while the test is negative),
and in the cases where hormones are used for
ovulation induction, like HCG, doing the
pregnancy test before 2 weeks can cause a false
positive result (which means that the patient is
not pregnant while the test is positive that is
caused by the HCG hormone that is found in the
blood).
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• If Intra Uterine Insemination fails, when can it
  be repeated, and how many times?

•  It can be repeated 3-6 times to increase the
  pregnancy rate

•  It can be repeated after at least one month or
  more, this depends on the doctor's and the
  couple's mutual decision

• If IUI fails after 4 trials, it is preferred not
  to repeat it. The doctor will decide the next
  step according to the case

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