Title: Radiation Safety Training
1Radiation Safety Training
- Short course at
- MSUM
- Radiation Safety Officer
- Joseph J Provost
2Introduction
- Radiation and radioactive materials can be
valuable tools in research - There are 3 labs using radioactive isotopes at
MSUM - Radioactive materials are used in a variety of
disciplines, ranging from the biological sciences
to physics even art!
3Radiation and You
- Radiation and radioactive materials are safe if
used properly - Background radiation is the ionizing radiation
emitted from a variety of natural and artificial
radiation sources
Your exposure can never realistically be zero,
because background radiation is always present
4Decay
- Radiation from radioactive materials is the
result of radioactive decay. An atom with an
unstable nucleus will decay until it becomes a
stable atom, emitting radiation as it decays.
5Introduction
- Radioactivity comes from the atomic nucleus, not
from the electron cloud. - Without instruments, radioactivity cannot be
seen, felt, smelled, tasted, or detected by human
beings. - For this reason, it went undiscovered until this
century.
6Where Does It Come From?
- Radiation results from an unstable nucleus
e-
e-
H-3
This is called radioactive decay
7Who found it?
- 1896 Henri Becquerel discovered natural radiation
- Uranium energy captured by phosphorus and X-Ray
film - Marie Curie - student of Henri, determined the
emissions were radiation and found the
radioactive element - Radium and Polonium. First
person to win two Nobel Prizes in two fields
(1903 and 1911) one with HB and one with her
husband - Irene Joliot-Curie - induction of radioactive
material Ni, P and Si (1935 Nobel Prize)
8Decay
- For example, the H-3 (also known as tritium)
nucleus consists of one proton and two neutrons.
When undergoing radioactive decay, one of the
tritium neutrons emits an electron and becomes a
proton resulting in He-3, which has three protons
and one neutron.
e-
3H
3He
9- Sometimes a substance will progress through
several radioactive decays until it reaches a
stable state.
10Where Does it Come From?
- Radiation results from an unstable nucleus
e-
e-
He-3
H-3
- This is called radioactive decay
11Nuclear Arithmetic
- Protons and neutrons are collectively called
nucleons - where
- 1. Number of neutrons A-Z
- 2. The nucleon number of an isotope is written as
a suffix to the name ex. Hydrogen - 2
X chemical symbol A nucleon number (sum of p
and n) Z atomic number ( of p)
12Transmutation
- Not all nuclei are radioactive
- OF ALL OF THESE ARE ISOTOPES, ONLY ONE IS
RADIOACTIVE!
13Transmutation
- Not all nuclei are radioactive. Some nuclei are
stable while other are radioactive those that
are radioactive are sometimes referred to as
RADIOISOTOPES. -
14Radioactive Decay
- Radioactive decay is a random event
- Half life is the time it takes for half of the
nuclei is a substance to undergo radioactive
decay
of unstable nuclei
long half life
short half life
Time
15Half Life
- Radioactive decay occurs randomly, that is, it is
not known when
individual atoms will undergo decay. However,
although the decay of individual atoms is random,
a radioactive substance, consisting of many
atoms, will decay according to a known pattern.
16- A property often used to describe a radioactive
substance is known as the half-life. - The half life is the time it takes for half of
the unstable nuclei in the radioactive substance
to undergo radioactive decay.
17For example, the half-life of P-32 is 14.3 days.
- If you start with 100 microcuries(the unit of the
microcurie will be explained later) of P-32 ,
after 14.3 days there would be 50 microcuries
left. - After another 14.3 days there would be 25
microcuries left. - After 10 half-lives, only about 1/1000th
(actually 1/210, which is 1/1024) of the original
will be left.
18- There is a wide range of half-lives for
isotopesThe half-life of P-32 is only 14.3 days
whereas the half-life of C-14 is 5730 years
19Radioactive decay Equation
- Activity(A)number of nuclei (N) that decay per
unit of time - A(t) dN/dt -lN(t) A(t) AOe-lt
AO
initial activity
of undecayed nuclei (N)
l is called the decay constant
time(t)
20Half-life the Decay Constant
- Half-life (t1/2) is related to the constant
according to this equationt1/2 (ln 2)/l
AO
Activity
1/2 AO
1/2 AO
t1/2
t1/2
Time
21Radioactive Emissions
- Alpha particles
- Beta particles
22Radioactive Emissions
- Alpha particles contain two protons and two
neutrons (a helium nucleus). They have an atomic
number of 2.
23Properties-Alpha Particles
- consist of 2 protons and 2 neutrons
- have 2 charge
- can only travel up to a few centimeters in air
- are stopped by the protective layer of your skin
2
24Alpha emitters
- We do not currently use isotopes which emit alpha
particles - Generally these are elements which are very heavy
- Atomic Number greater than 83
- Thorium, radon and so on.
25Radioactive Emissions
- Alpha particles contain two protons and two
neutrons (a helium nucleus). They have an atomic
number of 2. - Beta particles
26Radioactive Emissions
- Alpha particles contain two protons and two
neutrons (a helium nucleus). They have an atomic
number of 2. - Beta particles are simply electrons. Beta
radiation is a stream of electrons.
27Properties - Beta Particles
b
b
- Beta particles
- are either an electron (-1 charge) or positron
(1 charge) - travel about 12 feet per MeV in air
- Higher energy betas should be shielded with low Z
materials such as Plexiglas/Lucite or wood
b-
28Typical beta isotopes
- We use several ß emitters at MSU. These can be
classified as low or high energy particles
29Radioactive Emissions
- Gamma rays
- Positron emission
30Radioactive Emissions
- Gamma rays are a high energy form of
electromagnetic radiation. They are similar to
light waves but have shorter wavelengths and are
more energetic. - Positron emission
31Properties - Gamma Rays
- Gamma rays
- are photons that originate from the nucleus of
the atom - do not carry a charge
- can cause ionization when they interact
- should be shielded with high Z materials, such as
lead, if appropriate
32- Some possible gamma emitters
- 22Na
- 36Cl
- 125I
- 131 I
33Radioactive Emissions
- Gamma rays are a high energy form of
electromagnetic radiation. They are similar to
light waves but have shorter wavelengths and are
more energetic. - Positron emission equal in mass to beta particles
but opposite in charge
34Radiation particles
35Properties - Characteristic X-rays
- Characteristic X-rays are generated when
electrons fall from higher energy to lower energy
electron shells
e-
e-
e-
e-
e-
e-
X
36Properties - Bremsstrahlung X-rays
- Bremsstrahlung X-rays are created when electrons
are slowed down in the field of a nucleus
e-
X
e-
37Penetrating Power
- The penetrating power of radiation varies in
part due to their masses and their charges - Protection from radiation - distance and shielding
38Penetrating Power
- Alpha - outside of body little damage, not able
to penetrate skin. Inside of the body causes
much damage to tissues cells DNA and Proteins - Beta - some harm but much less than alpha can go
through skin
- Gamma - is the most harmful easily penetrates
skin and damages DNA and Cells as it rips
through
39Exposure
- Elements tend to concentrate in certain parts of
the body - I - Thyroid
- S - Skin
- P - Bone
- H - Throughout
40Radiation Units
- There are specific units for the amount of
radiation you receive in a given time and for the
total amount of exposure you are subjected to.
41Measuring radioactivity rates -What Is a Curie?
- This is the amount of radioactivity in a sample
(the amount of radioactivity activity) - A commonly-used unit for measuring activity is
the curie(Ci) - 1 curie is equal to 2.2 x 1012 disintegrations
per minute (dpm) - Typical activities found in a university lab are
in the microcurie (mCi) to millicurie (mCi) range
42Measuring radioactivity rates- What is a
Becquerel (Bq)
- The amount of radioactive material which decays
at a rate of one disintegratration per second
(dps) - This is the SI unit of radioactive material or
activity
43CPM DPM
- CPM is the counts per minute that a detector
sees - DPM are the actual disintegrations (release of
energy) by a radioactive sample disintegrations
per minute - Since detectors arent 100 efficient...DPM
CPM / Detector Efficiency(the detector
efficiency for the specific radioisotope, that is)
44Radiation Dose vs Rate
- Dose is the amount of radiation you were actually
exposed to - Roentogen - This can only be used to describe an
amount of gamma and X-rays, and only in air. One
roentgen is equal to depositing in dry air enough
energy to cause 2.58E-4 coulombs per kg. It is a
measure of the ionizations of the molecules in a
mass of air. (NOT a or b particles)
45What is a REM?
- REM - The most common used unit for measuring
radiation dose in people is the rem - REM Roentgen equivalent for man, a roentgen (an
international unit of X- or gamma-radiation)
adjusted for the atomic makeup of the human body - Since the rem is a relatively large unit, it is
more common to use the millirem (mrem), which is
1/1000th of a rem
46Rem is a Dose equilavent
- The Dose equivalent is the product of the
absorbed dose in tissue times a quality factor - This relates the absorbed dose in human tissue to
the effective biological damage of the
radiation. - Not all radiation has the same biological effect,
even for the same amount of absorbed dose. - Rem Quality factor x dose in rads
- Sievert is the SI unit of dose equivalent
47Quality factors
- X and gamma rays 1
- Beta particles 1
- Thermal Neutrons 2
- Fast Neutrons 10
- Protons 10
- Alpha particles 20
48Other Dose Units
- Rad (Radiation Absorbed Dose)- this is the amount
of exposure to any type of material from any type
of radiation measured in Joules/kg tissue - The Gray is the absorbed dose that corresponds to
the transfer of 1 joule to 1 kg of material (SI
unit). Does not relate to biological effects.
49Background Radiation
- Natural sources 300 mrem Medical 53 m
- Occupational 0.9 mrem Nuclear Fuel 0.05 mrem
- Consumer products 5-13 mrem
- Misc. environmental 0.06 mrem
From NCRP Report 93
50Occupational Radiation Exposure Limits
- Whole body 5,000 mrem/year
- Extremities 50,000 mrem/year
- Eye 15,000 mrem/year
- Fetus 500 mrem/gestation period (declared
pregnancy) - Minors 500 mrem/year
- Rad workers 100 mrem/year over background
51Review
- Rate - of disintegration
- DPM
- Curie
- Becquerel (SI)
- NOT CPM
- Dose - amount of radiation exposed
- Roentogen
- Rad
- Gray (SI)
- REM (equivalent)
- Sievert (SI equivalent)
52Declared Pregnant Woman
- A woman who has voluntarily informed the
Radiation Safety Section in writing of her
pregnancy and estimated date of conception
53Relative Risk -A Comparison
Examples of relative risk adapted from Cohen and
Lee, A Catalogue of Risks, Health Physics,
vol. 36, June 1979.
54Reduction in life span
- Activity Avg. Reduction
- Living in a city Vs country 5 years
- Single Vs. Married 5 years
- Male Vs female 3 years
- Radiation
- Cosmic 25 days
- Medical 30 days
- Terrestrial 50 - 100 days
- World fallout 1 day
55Biological effects
- Two types stochastic and non-stochastic
- Stochastic effects
- Stochastic effects are associated with long-term,
low-level (chronic) exposure to radiation.
("Stochastic" refers to the likelihood that
something will happen.) - Increased levels of exposure make these health
effects more likely to occur, but do not
influence the type or severity of the effect. - The severity of the ultimate effect is not linked
to the amount of the dose - There is NO threshold for the effects to be
observed - Rad safety assumes no safe amount.
56Somatic, Prompt Effects
Acute Dose (rem) Syndrome 1 - 25 No
detectable effects 25 - 100 Slight sickness
RBCs drop 100-1000 Hemopoietic 1000-5000 Gas
tointestinal 5000-10000 Central Nervous System
57Gamma Radiation
- Absorbed Dose Survival Probability
- 100 rad Virtually certain
- 100 - 200 rad Probable
- 200 - 450 rad Probable
- 500 - 600 rad Almost impossible
- 900 - 1200 rad Possible in some cases
- with bone marrow t-plant
58Non-stochastic effects
- Severity of the result is related to the dose
(usually high dose). - Adverse effect happens soon after exposure and
can be directly linked to exposure - Generally related to a large dose over a short
time - There is a threshold level - observed effects
follow typical distribution around a dose
59Cancer Risks
Excess Cancer Deaths after Acute, one-time
exposure to 10 rem per 100,000 People (BEIR V)
Adult Leukemia 95 Cancer of
digestive system 230 Cancer of Respiratory
System 170 Leukemia risk (without excess 10
rem) was 685 excess deaths per 100,000 people
(1980 Vital Statistics of the U.S.)
60Teratogenic Effects
Another class of biological effects of concern
are called the teratogenic effects.
Teratogenic effects are effects which occur in
offspring as a result of exposure to a hazard
while in-utero
61Maternal Factors Pregnancy
62Occupational Dose
Annual Limits For Workers
- Whole body(active blood forming organs) 5 REM
- Eyes - 15 REM Extremities - 50 REM
- Minors (10 of adult limits)
- Embryo/Fetus - 0.5 REM over the entire pregnancy.
Annual Limits For General Public
- Total Effective Dose Equivalent lt 0.1 REM
63ALARA
As Low As Reasonably Achievable
MSUM is committed to keeping radiation
exposures to personnel ALARA
64ALARA
Education - Ensure proper training and use
reduces unnecessary exposure Dose - The lower the
dose the better, but all within reason Reasonable
- is determined on a case by case basis with the
PI and RSO Protection - Use proper shielding and
reduce time of exposure
65Radiation Protection
The three principles of radiation
protection Time Distance
Shielding
66Time
Decreasing the time spent near a radiation
source decreases radiation exposure
67Distance
Increasing the distance from a radiation source
decreases radiation exposure
68Shielding
Increasing the shielding of a radiation source
decreases radiation exposure
shield
69Shielding Beta Emitters
- H-3, C-14, S-35 do not require shielding for the
quantities typically in use. - Higher energy beta-emitters, such as P-32, may
need to be shielded - Shield with low Z materials, such as Plexiglas or
wood - Do NOT shield with high Z materials, such as
lead- you can actually generate additional
radiation in the form of x-rays!
70Shielding Gamma Emitters
- Lead Shielding is not required for most
quantities of gamma emitters in use, such as
I-125 or Cr-51 - If lead shielding is used, be careful not to
contaminate it with long-lived radioisotopes
71Protective Clothing
- Gloves
- Lab Coat
- Eyewear
- Closed toe footwear
72Contamination Control
- Watch out where you put your hot little hands
during an experiment - Monitor yourself and your work area frequently
for radioactivity - Make sure to wash your hands after finishing an
experiment
73Avoid Ingesting Radioactive Material
- Dont bring hands or objects to your mouth when
performing an experiment - Eating, drinking, smoking, and applying cosmetics
are strictly forbidden in radioisotope use areas - Never mouth pipette
- Food doesnt belong in a refrigerator which
stores radioactive materials
74Avoid inhaling radioactive material
- Make sure that you have proper ventilation for
your experiment - When using volatile materials, use a fume hood
which has been certified
75Radioactive Signs Labels
Radioisotopes use areas should be
clearly marked Use warning signs/ labels
on - work areas - rad waste containers
- sinks - refrigerators - equipment
76Using H-3 (Tritium)
- Betas from H-3 are stopped by the protective
layer of your skin- shielding is not needed for
quantities typically in use at MSUM - H-3 tends to creep - do not store tritiated
water in refrigerators or freezers without
keeping in a sealed container - Can not detect by Geiger counter - must use a
wipe test.
77Using C-14 S-35
- Shielding is not needed for quantities typically
in use at MSUM - Spot checks for contamination can be performed
using direct monitoring, but contamination
surveys must be performed using a swipe survey - These isotopes can not be detected by Geiger
counter.
78Using P-32
- If shielding is needed, use a low Z material such
as wood or Plexiglas - Do NOT use lead shielding- x-rays can be
generated - Geiger counter or wipe test will measure this
isotope.
79Using Carrier-free I-125
- Perform iodination as quickly as possible in a
certified fume hood - Reduce (iodine to iodide) all fractions, liquid
waste and equipment used ASAP - Store unused portions and items which cannot be
reduced inside a sealed bag with activated
charcoal in a fume hood - Geiger counters will detect this isotope
80General Spill Procedures
- When cleaning up a spill, place absorbent
material around the edges of the spill and clean
from the outside edges of the spill towards the
center to avoid spreading contamination - Place materials used to clean the spill into the
appropriate radioactive waste containers - The Radiation Safety Officer can provide advice
to lab personnel regarding decontamination
procedures
81Minor Radioactive Spills
- A minor spill is one that involves small
quantities/activities/energies of radioactive
material confined to a relatively localized area - Most spills that occur in the lab are minor, and
should be cleaned up by lab personnel ASAP - You do not need to inform the Radiation Safety
Officer in the event of a minor spill
82Intermediate Spills
- An intermediate spill may involve larger amounts
of radioactive material spread over a greater
area - Intermediate spills can also involve small
amounts of more hazardous radioactive materials,
e.g., higher energy emitters
83Intermediate Spills- What to Do
- Confine contamination with absorbent materials
- Check yourself for contamination before leaving
area remove contaminated clothing and shoes. - Restrict access to the spill area
- If the spill involves a volatile material,
increase ventilation if it is a dry spill,
decrease ventilation
84Intermediate Spills- What to Do(cont..)
- If contamination is widespread outside the lab,
it may be necessary to contact campus police to
assist with traffic control - Contact the Radiation Safety Officer (5085/4323)
to report the spill - Do not attempt decontamination unless the
situation threatens to become much worse
85High Level Spills
- Protecting personnel is the FIRST priority
- If high level exposures or airborne contamination
are possible - evacuate area immediately -
rid yourself of contamination - keep others out
of area
86And Another Thing About Spills
You will not be penalized for reporting a spill,
but on the other hand.
87Radiation Survey Requirements
- When should Surveys be conducted?-
- Whenever radioactive materials are present in the
lab, contamination surveys MUST be performed and
documented at least once a week. - The area you are working with must be surveyed
before finishing for the day. - If no experiments are being conducted, it is
permissible to halt tests until starting again.
88Contamination Surveys
- Direct monitoring with a Geiger counter can be
performed when using P-32 and other high energy
beta emitters - Swipe surveys must be performed for low energy
beta emitters (e.g., H-3, C-14, S-35) and must be
counted in a liquid scintillation counter or
equivalent instrument - Direct monitoring with a low energy gamma probe
(NaI) can be performed when using gamma emitters
such as I-125
89General Survey Information
- Randomly survey selected areas outside of normal
radioisotope use areas at least once a month - Using a map of your lab can make documenting
surveyed areas easier - Look for levels twice as large as the background
- Check for contamination wherever human hands
normally go...
9010 Most Often Contaminated Sites
10. Soap/towel dispenser 9. Microwave
oven 8. Radio dials 7. Phones 6. Pens/pencils
5. Chairs 4. Drawer handles 3. Refrigerator h
andles 2. Lab books
1. Geiger counters
91Documenting Surveys
- Contamination surveys must be documented
- Record the following - date performed -
area(s) surveyed ( a map helps!) -
results - identity of surveyor -
instrument used - action taken is
contamination is found
92(No Transcript)
93(No Transcript)
94Step-by-step Guide to Direct Monitoring - Before
You Start
- 1 Don protective
- equipment (e.g. gloves)
- 2 Check your Geiger
- counter
- - battery test
- - note background
- radiation level
- - turn on speaker
- - check probe with
- check source
95Step-by-step Guide to Direct Monitoring, How-to
- 3 Switch Geiger counter to lowest multiplier,
usually X1 - 4 Hold probe window 1 cm from the surface you are
surveying - 5 Move probe over surface at a rate of about 1
cm/second - 6 If surveying for alpha or beta contamination,
do not cover probe with parafilm or plastic wrap
96Step-by-step Guide to Swipe Surveys- General Tips
- Change gloves frequently
- Avoid cross-contaminating samples
- Use filter paper or cotton swabs
97Step-by-step Guide to Swipe Surveys, How-to
- 1. Don protective equipment (e.g., gloves)
- 2. Lightly moisten swipe with alcohol or water
- 3. Using uniform pressure, swipe an area about
100-200 cm2 (survey a discrete area so that if
contamination is found the area will be easier to
identify)
98Radioactive Material Delivery
- Deliveries are generally performed every weekday
afternoon except for University holidays - All packages are delivered the same day that they
are received we will not hold a package unless
absolutely necessary - If you did not receive a package you were
expecting, contact your business office, the
vendor and the carrier before calling the
Radiation Safety Officer
99Receipt of Radioactive Materials
- Open containers with volatile, gaseous or readily
dispersible materials in a fume hood - When you receive your shipment, check the inner
container for leakage- a simple swipe test is
sufficient - If there is a problem with the shipment, notify
the Radiation Safety Officer immediately - Remember to document the receipt if radioactive
material in your labs records
100Personnel Monitoring
- Personnel monitoring devices are assigned at the
discretion of the Radiation Safety Officer in
accordance with all applicable rules and
regulation
101The Care and Feeding of Your Dosimeter
- Always
- make available for exchange on the appropriate
exchange date - report contamination of dosimetry
- store away from radioactive sources
- Never
- share dosimetry
- remove film from holder
- expose to heat
- take off campus
- intentionally expose to radiation
102Wearing Dosimeters
- Whole Body
- wear between neckline and waist unless otherwise
instructed - wear with name on badge facing outwards
- Extremity
- the label side of the ring should usually face
the palm - wear gloves over ring, if possible
103Missing Dosimeters
- If you lose, damage or fail to make dosimeters
available for exchange you will be required to
provide a detailed description of all radioactive
sources in use during the wear period
104Storage of Radioactive Waste
- Each radioactive waste container must have a
Caution Radioactive Materials sign/label - Radioactive waste containers must be stored in a
controlled area
105Radioactive Waste Types
Solid
Liquid
Sharps
Carcass
106Solid Radioactive Waste
- Segregate waste into three categories
- glass and plastic that cannot be decontaminated
easily - paper, gloves, etc.
- short-lived waste (T1/2 lt 90 days) to be held for
decay - Line containers with clear plastic bags at least
4 mils thick - Do not put liquids into the solid waste
107Liquid Waste
- Organic
- store in 1 - 5 gal plastic carboys with outer
containment - filter out solids (use 60 mesh screen)
- pH must be adjusted to between 6.8 and 8.0
- Aqueous
- low activity waste can be disposed into the
sanitary sewer system in specific amounts and/or
concentrations with prior approval from the
Radiation Safety Officer only
108Radioactive Sharps
- radioactive sharps are items such as Pasteur
pipettes, syringes and hypodermic needles - most glass items (test tubes, vials, etc.) can be
decontaminated and should not be disposed of as
radioactive sharps
109Radioactive Carcasses
- Prior arrangements must be made with the
Radiation Safety Officer for disposal of
radioactive carcasses
110User Definitions
Principle Investigator - Tenure Track MSUM
Faculty. Approved by Radiation Safety
Committee Workers - Those staff or research
students, who are using radioactive materials
under the supervision of a principle investigator
111User Responsibility
- Principle Investigator -Ensure that all
procedures are authorized and followed. - - Ensure surveys are conducted and reported
- Monitor use and disposal of isotopes
- Ensure their workers are trained
- Workers - Must be trained and pass short course
test - Must practice ALARA and monitor use
- Conduct surveys and report spills or contamination
112SL 222 Access
Principle Investigator - Has full access to side
rooms and main room keys Workers - May only have
access to outside doors of SL222 after passing
test. Can not have full access to side rooms.
Must get those keys from PI.
113MSUM Radiation Safety Manual
- The MSUM Radiation Safety Manual contains
information that all users of radiation sources
at MSUM should know
- Permission to use
- Worker and PI responsibilities
- Health Definitions
- Forms in the handbook and on the web
- www.mnstate.edu/provost/radsafe.html
114MSUM Radiation Authorization
- Rad Safe Test - take on your own
- You must take the MSUM Rad Safe test and pass
with a score of 75 - The test is found on-line.
- Sign and agree to info on the test form
- Complete forms 1 and 2 (also found online)
- Turn forms and test to Dr Provost
- Orientation - you must make appt
- Conducted by RSO (Dr. Provost)
- Tour / review of site and storage
- Answer questions on use and procedures
- Wipe test/Survey review
- Key control / access privilege
- Web site Handbook review