Update from NIDCR

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Update from NIDCR

• USPHS Scientific and Training Symposium
• June 10, 2008

Isabel Garcia, DDS, MPH
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Greetings from the NIH and NIDCR
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Diverse and Complex Oral Diseases
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NIH Budget FY 2007 29.0 Billion

• NIDCR Budget
• FY 2007 389.7 Million

• 1.3 of total NIH budget

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NIDCR Appropriations
Net loss of 11 purchasing power
Less Roadmap Biomedical Research and
Development Price Index
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How best to exploit research opportunities during
challenging times?

• Planning
• Prioritization
• Guiding principles
• Partnering

Scientificopportunity
PublicHealthNeeds
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Informing and Transforming Dentistry through
Research
Predictive Personalized
Preemptive
Participatory
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Informing and Transforming Dentistry through
Research
Predictive Personalized
Preemptive
Participatory
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Using saliva as a diagnostic fluid

• Most analytes found in blood can be measured in
  saliva
• Safe, acceptable, non-invasive, painless
• Self collection possible
• Economical

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Transformation of Dentistry through Discovery
Predictive Personalized
Preemptive
Participatory
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Personalized Medicine

• Side effects, risk of overdosing, intoxication,
  even death can occur if rapid metabolizers of
  drug enzymes (e.g. codeine, heparin, cancer
  drugs)
• Using the right dose of the right drug for the
  right reason for the right patient at the right
  time
• Ongoing studies on narcotics and pharmacogenomics
  of fluoride

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Transformation of Dentistry through Discovery
Predictive Personalized
Preemptive
Participatory
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Craniofacial malformations are the most common
of all human birth defects Genes and Environment
play a role
Preemption Identifying Disease Susceptibility
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Women who smoke during pregnancy and carry a baby
whose DNA lacks both copies of a certain gene
involved in detoxifying cigarette smoke has a 20
times greater chance of having a baby with an
oral cleft
Craniofacial and Oral Gene Expression
Network http//hg.wustl.edu/COGENE/
Am J Human Genetics 8076. 2007
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Transformation of Dentistry through Discovery
Predictive Personalized
Preemptive
Participatory
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Dental Practice Based Research Networks

• Study common clinical questions faced by dentists
  in everyday practice
• 800 dentists participating
• Studies across 25 states and also Sweden, Denmark
  and Norway
• Studies involve dentists both in initiation and
  conduct of the research

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Addressing Oral Health Disparities
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Centers for Research to Reduce Oral Health
Disparities
Co funded by National Center for Minority
Health and Health Disparities
NIH Office for Behavioral and Social
Sciences Research
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Photos Courtesy of Amid Ismail University of
Michigan
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Photos Courtesy of Francisco Ramos-Gomez UCSF
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Photos Courtesy of Philip Weinstein University of
Washington
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Photo Courtesy of Peter Milgrom University of
Washington
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Other areas of support include

• Association of oral and systemic disease
• Risk factors for TMJD
• Nanotechnology to improve dental composites
• Salivary gene transfer
• Oral Microbiome metagenomics
• Behavioral and Social Science research
• Tissue Engineering and regenerative dental
  medicine
• And more..

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