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BIOSCAN S'A'

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Directory. Chairman: Rinaldo Zecchetto, Industrial Civil Engineer. ... Commercial agreements with hospitals and clinics laboratories. Human Health Customer ... – PowerPoint PPT presentation

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Title: BIOSCAN S'A'


1
BIOSCAN S.A.
  • Chile - 2006

2
Summary
  • Mission/Vision
  • Company history
  • Laboratory
  • Detection of human pathogens
  • Detection of plant viruses
  • Research

3
Interest Areas
  • Molecular diagnostic and clinical trials
  • Seaweeds small molecules with biological
    activities

4
Chart
5
Directory
  • Chairman Rinaldo Zecchetto, Industrial Civil
    Engineer.
  • Director Alejandra Moenne, PhD, Biochemistry and
    Molecular Biology.
  • Director Pier Zecchetto, Industrial Civil
    Engineer.
  • Director Patricio Arce, PhD, Plant Molecular
    Biology.
  • CEO Roberto Valladares, Industrial Civil
    Engineer.

6
Scientific Advisory Committee
  • Scientific Director Patricio Arce, PhD, Plant
    Molecular Biology. Pontificia Universidad
    Católica de Chile.
  • Scientific Advisor Alejandra Moenne, PhD,
    Biochemistry and Molecular Biology. Universidad
    de Santiago de Chile.
  • Medical Director MD. Antonio Banfi, Pediatrics.
    Universidad de Chile.

7
History
  • 1994. Began operation by developing the PCR
    detection of 12 periodontal pathogens
  • 1996. Development of gynecological pathogens
    detection
  • 1998. First international publication. Am. J.
    Obst. Gynecol. 1998 179 1115-9.
  • New stockholders June 2005

8
History
  • 2004. PCR detection of 23 RNA viruses in fruit
    trees. (CORFO grant)
  • 2005. New facilities
  • 2005. Patent pending algal sulfated galactan, as
    a plant immunity stimulator
  • 2005. Fruit fingerprinting project (FONDEF grant)

9
Facilities and Personnel
10
Facilities and Personnel
  • 330 m2
  • Molecular biology infrastructure including 4
    separated working areas
  • Unit of biosafety level II
  • 14 staff

11
Human Pathogens Detection
12
Human Pathogens Detection
  • PCR detection of 50 human pathogens
  • 160.000 detections
  • CAP Surveys Program ID and HC-6
  • 25 hospital an clinics
  • 400 physicians
  • LCR, LA, uterine, tissue, blood and sputum
    specimens

13
Commercial Activities
  • Medical visit and presentation to clinicians of
    different specialities gyneco-logy and
    obstetrics, dermatology, urology, pediatric,
    critical care, pulmonary, etc.
  • Contact with hospitals ethic committees and
    regulators
  • Congress 3 people sale team
  • Presentation in Congresses
  • Commercial agreements with hospitals and clinics
    laboratories

14
Human Health Customer
  • Clínica Las Condes
  • Clínica Tabancura
  • Clínica Indisa
  • Hospital Luis Calvo Mackenna
  • Hospital Luis Tisné
  • Hospital San Borja
  • Other Clinic and Hospital(19)
  • Medical Center (45)
  • Medical offices (330)

15
Gynecological Pathogens
  • Human papilloma virus
  • HPV types 6, 11, 16, 18, 31, 33, 45, 56, 58, 59
  • Streptococcus agalactiae
  • Chlamydia trachomatis
  • U urealyticum/parvum
  • Mycoplasma hominis
  • Neisseria gonorrhoeae
  • Treponema pallidum
  • Candida spp.
  • Trichomonas vaginalis
  • Enterococcus spp.
  • Escherichia coli
  • Proteus spp.
  • Herpes simplex virus 1
  • Herpes simplex virus 2
  • Gardnerella vaginalis
  • Mobiluncus spp.
  • Prevotella spp.
  • Porphyromonas spp.
  • Bacteroides fragilis
  • Peptostreptococcus anaerobius
  • Fusobacterium spp.
  • Staphylococcus aureus
  • Actinomyces israelii
  • Listeria monocytogenes
  • Haemophilus influenzae

16
Periodontal Pathogens
  • Streptococcus mutans
  • Actinobacillus actinomycetemcomitans
  • Porphyromonas gingivalis
  • Prevotella intermedia
  • Tannerella forsythia
  • Treponema denticola
  • Fusobacterium nucleatum
  • Peptostreptococcus micros
  • Campylobacter rectus
  • Eikenella corrodens
  • Prevotella nigrescens
  • Capnocytophaga spp.
  • Streptococcus intermedius

17
Investigations
  • Amniotic Fluid Pathogens detection
  • Hospital Clínico Universidad Católica
  • Streptococcus agalactiae, Mycoplasma and
    Ureaplasma detection in pregnant women
  • Hospital Luis Tisné
  • Clínica Las Condes
  • Treponema pallidum detection in newborn children
  • Hospital Padre Hurtado

18
Investigations
  • Gynecological Pathogens PCR detection
    (Ureaplasma, Mycoplasma, HPV, G. vaginalis,
    Prevotella spp., Candida spp. y N. gonorrhoeae)
  • Universidad de los Andes/CUEM Hospital
    Parroquial San Bernardo
  • Effect of C. trachomatis infection in tubal
    pregnancies
  • Hospital Parroquial San Bernardo

19
External Quality Control
CAP (College of American Pathologists) Surveys
Program
  • HC6 Chlamydia/NGC Nucleic Acids Amplification
  • Chlamydia trachomatis y Neisseria gonorrhoeae
    PCR detection
  • ID Human Papillomavirus y Human herpesvirus 1-2
  • HPV and HSV 1-2 PCR detection

20
Development
  • Herpes virus family Zoster (type 3),
    Epstein-Barr (type 4), Cytomegalovirus (type 5)
  • Mycobacterium tuberculosis complex
  • (M. tuberculosis, M. microti, M. bovis, M.
    africanum, M. canetti)
  • Mycobacterium avium complex
  • (M. avium, M. intracellulare)
  • Bordetella pertussis, Mycoplasma pneumoniae,
    Chlamydia pneumoniae, Legionella pneumophila

21
Plant Viruses Detection
22
Project Description
  • Detection of 23 viruses in grapes, pipfruit and
    stonefruits by RT-PCR
  • Project Importance
  • - There is no plant antiviral
  • - Sanitary authorities check viruses to
    consider a plant as virus-free
  • - Viruses decrease production and quality of
    fruit and wines
  • Started January 2005

23
Team
  • Head Investigator Alejandra Moenne, Biochemist,
    PhD Molecular Biology
  • Project Manager Carolina Uquillas, Agronomist,
    PhD Molecular Biology
  • Investigators Luis Lizama, Biochemist and
    Jeannette Vera, Biochemist.
  • Bioscans laboratory team

24
Grapevine Viruses
  • Arabis mosaic
  • Grapevine fanleaf virus
  • Grapevine fleck virus
  • Grapevine leafroll associated virus 1 to 7
  • Grapevine rootstock stem virus
  • Grapevine vitivirus A
  • Grapevine vitivirus B
  • Rupestris stem pitting-associated virus
  • Strawberry latent ringspot virus
  • Tobacco ringspot virus
  • Tomato ringspot virus

25
Pipfruits and Stonefruits Viruses
  • PIPFRUITS
  • Apple chlorotic leafspot virus
  • Apple mosaic virus
  • STONEFRUITS
  • Apple chlorotic leafspot virus
  • Cherry leafroll virus
  • Plum pox virus
  • Prune dwarf virus
  • Prunus necrotic ringspot virus
  • Tomato ringspot virus

26
Sales and Marketing
  • First sale in September 2005, grapes virus.
  • Contacts established with 10 top nurseries y 5
    main vineyards

27
Research and Development
28
Development Projects
  • 40 kits for real time PCR for human pathogens
    detection respiratory, gineco-obstetric,
    perinatal and pediatric (A.Banfi L.Lizama)
  • Bioprospection of algal small molecules with
    biological activities (A.Moenne J.Correa)
  • Grape vine, apple, pear, peach and strawberry
    fringerprinting (P.Hinrichsen, INIA)

29
Research Projects
  • Sulfated Galactan potential plant antiviral
    (A.Moenne)
  • Virus cleaning for grapes, pipfruits and
    stonefruits master trees
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