BIO-NANO TECH IN USA

1
-Introduction-
BIO-NANO TECH IN USA ????.????????? ???81366?????
?422-1? TEL[phone] FAX[phone]
2
Brand Story
MLE GOWOONSESANG is an anti-aging product of
NeoPharm for sensitive skin. New paradigm of skin
science MLE and scientific know how of
GOWOONSESANG clinic cosmetics for skin care meet
new unique skin physiology activator, K5. This
will provide the customers with the
differentiated product, faith and trust.
3
MLE an Another Skin
The skin barrier function weaken with the age.
The stratum corneum is the most important for
skin barrier function, which is composed of
corneocyte and lamellar structured intercellular
lipids. 1) The disturbance of lamellar structure
of intercellular lipid is main reason of the
weakness of skin barrier function, resulted in
sensitive and dry skin, make accelerate the skin
ageing. The lamellar structure show very
characteristic Maltese cross texture under
cross polarized microscope. Maltese cross was the
symbol of Christian warriors known as the Knights
Hospitaller. 2) Recently, skin science have
tried to make same lamellar structure with the
that of the skin because the well-ordered
lamellar is very important for healthy and
beautiful skin. NeoPharm developed the same
lamellar structure with that of skin. It shows
Maltese Cross texture under cross polarized
microscope,3) show the same lamellar patterns
with that of skin. 4) MLE has same structure
with skin, show high compatibility with skin. It
is an Another skin because it recover skin
barrier function of sensitive and dry skin due to
the ageing and results in healthy and beautiful
skin give the skin barrier function.
Ref. Journal of Investigative Dermatology,
121794-801,2003
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MLE New Paradigm of Skin Science
MLE credited by Dr. Baumann from Miami Univ in
USA
-MLE in the World-
K2 Shaving Product (UK)
NeoPharm, a Korean company that makes a skin
care line called ATOPALM, has taken it a step
further. They have proven that their moisturizer
is able to mimic the same three- dimensional
structure that your native skin barrier
has. Ref. Skin Type Solution by MD. Leslie
Baumann, Random House p.360 (2006) NeoPharms
MLE is new Paradigm of Skin Science which was
credited internationally.
CERANADE (U.S.A)
5
MLE Public confidence
Annals of Dermatology
Journal of Investigative Dermatology
Russian Journal of Dermatology
Bulletin of Chem Technology
Korean Journal of Skin Barrier Research
Annual meeting of society of Investigative
Dermatology
Korean society of Cosmetic Dermatology
World congress of Dermatology(Paris)
Cosmetics Toiletry
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GWSS Representative Cosmeceutical Brand
GOWOONSESANG
GOWOONSESANG is, based on the best infrastructure
of medical skin care in which 8 medical doctors,
43 skin specialists, 114 nurses and 110
aestheticians specializing in skin in the
GOWOONSESANG dermatology are all participating in
the development, aiming at the top representative
Cosmeceutical brand in Korea. Based on the
understanding for the actual visiting customers
skin troubles, this reliable product developed by
participation of skin specialists and the
customers has been loved not only by the
customers in Korea but by those in Japan, Hong
Kong and South East Asia.
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MLE - GOWOONSESANG
GOWOONSESANG
MLE
New Paradigm of Skin Science
Medical Skincare (Cosmeceutical)
Sensitive Anti-Aging 1st Century with MLE
GOWOONSESANG
MLE GOWOONSESANG is a fusion brand of MLE that is
New paradigm for skin care science credited
worldwide and GOWOONSESANG Cosmetics that is a
leader in medical skin care field, based on the
counseling by dermatologists and skincare
specialists
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Recommended Anti-Aging care by Ph.D.Ahn
Recommended by Ph.D. Ahn of Gowoosesang Professio
nal Anti-Aging care
As the skin aging starts to make steady progress
since ones thirties, most of women are
complaining the skin troubles like dryness,
wrinkles, skin pigmentation problems,
sensitiveness and friableness etc. This is
because the skin elasticity becomes lower and the
skin barrier of epidermis is weakened, the skin
becomes dry and sensitive and the skin functions
are damaged from ultraviolet rays. Especially for
the sensitive skin, the skin barrier function are
weaker than that of the healthy and beautiful
skin, it can accelerate ageing process of
sensitiveness and dryness skin. Women are also
complaining the difficulties of anti-aging care
because of the skin-irritation from the existing
anti-aging products. So, in case of anti-aging
care for sensitive skin, it is more important to
care the recovery skin barrier function from the
damaged skin barrier, considering the
peculiarities of sensitive skin. On the outside,
we should prevent continuously from the
sensitiveness and dryness of epidermis and on the
inside we should care the anti-aging carefully to
provide the dermis with the functional activation
through low-irritation functional material, in
combination.
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Solution for sensitive anti-ageing
The collaborative research staffs of MLE
GOWOONSESANG pay attention to troubles are like
sensitization, dryness, over keratinization,
friableness, wrinkles and oxidation. We present
solutions for sensitive anti-ageing through K5
and MLE technology. K5 is new unique skin
physiology activator and MLE is New paradigm of
skin care.
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K5 New Anti-aging Activator
K5(K6PC-5), low skin-irritation and anti-aging
material K5 is an novel and unique ingredient for
low skin-irritation and anti-aging function that
works in epidermis and dermis. This is the new
concept of material to prevent from skin aging
and also improve the wrinkles from the skin
surface without skin-irritation. This is an
essential factor to realize the low
skin-irritation and anti-aging of MLE
GOWOONSESANG. It has been proved that it
normalizes the differentiate of keratinocyte,
increase the proliferation of fibroblast and
collagen synthesis and has an effect of reducing
wrinkles.

• Ref
• Journal of Lipid Research. Vol.48(2007.9)
• Korean Journal of Cosmetic Dermatology, Vol. 2.
  No.1, 9 17 pp
• Patent in Korea KR 10-0607438
• http//www.sciencedaily.com/upi/index.php?feedSci
  encearticleUPI-1-20070829-21062800-bc-skorea-lip
  ids.xml
• http//www.cosmeticsdesign-europe.com/news-by-prod
  uct/news.asp?id79325kpsoriasis-ceramides-lipid
• http//www.medicalnewstoday.com/articles/80823.php

K5(K6PC-5) INCI name Dihydroxyisopropyl Capryl
oylcaprylamide
Stimulate fibroblast proliferation collagen
synthesis keratinocyte differentiation
(Double action in dermis and epidermis )
Dry, Sensitive Anti-aging care Anti-Wrinkles
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K5 In vivo data of K5
K5 stimulated Collagen Synthesis and increase
skin barrier function
K5 increase Collagen synthesis and prevent
degradation induced by Photo-aging.
K5 increases the levels of differentiation of
Protein in the epidermis of aged skin.
Ref SID Meeting (2007.5)
Ref Journal of Lipid Research. Vol.48(2007.9)
K5 is non-irritable anti-ageing material. K5 did
not show the skin irritation compared with
Retinoic acid.
K5 promotes fibroblast proliferation by the same
level of Retinoic acid.
Ref SID Meeting (2007.5)
Ref Korean Journal of Cosmetic Dermatology, Vol.
2. No.1
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K5 Anti-Aging effect by K5
Anti-Aging In Vivo test of MLE containing K5(N
32) The clinical study conducted with 32 subjects
determines if K5 could show wrinkle-improving
effects. After 8 weeks application, instrumental
analysis revealed that it decrease the eye
wrinkles significantly. Ref Korean Journal of
Cosmetic Dermatology, Vol. 2. No.1, 917 pp
Many participants also said that the K5 cream
improved their skin conditions K5 cream
65.6, control cream 6.3, both 28.1
K5
Placebo
before
After 8 weeks
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Ascorbyl Pentapeptide
Ascorbyl Pentapeptide is compounds of Vitamin C
and Pentapeptide and it promote Collagen
synthesis.
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Product Concept
Aged skin from Weakening of dermis function
Aged skin from UV
Aged skin from damaged skin barrier function
Skin troubles are like sensitization, dryness,
friableness, wrinkles and oxidation
Skin barrier Anti-Aging Strengthen of damaged
Skin barrier function by MLE
In Out Multiple Anti-Aging IN Activation of
dermis, Promote fibroblast proliferation OUT
Normalized of differentiation of keratinocyte
Silk-Skin Anti-Aging Collagen Synthesis and
Anti-Oxidant by Ascorbyl Pentapeptide and Amino
Compound
Whitening Anti-Aging Arbutin 2, MLE
formulation, Photo-aging care
4 Anti-aging cares for Sensitive Skin New
paradigm for Aged Sensitive Skin
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Product Map
Daily skin care
Daily Anti-Aging
Special Care
Sensitive Skinewal Foam Cleanser 180ml
Sensitive Anti-Aging Activator 30ml
Sensitive Skinewal Facial mask 6sheets/pack
Sensitive Skinewal Toner 150ml
Sensitive Anti-Aging Eye Serum 15 ml
Sensitive Skinewal Eye gel sheet 10sheets/pack
Sensitive Skinewal Emulsion 150ml
Sensitive Skinewal Day Cream SPF10 50ml
Sensitive Skinewal Night Cream SPF10 50ml
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Product Characteristic
Sensitive Skinewal Foam Cleanser
Weak acid Washable gel type Foam Cleanser
Characteristic

• Weak acid and low skin irritation gel type
  washable cleanser
• Anti-inflammation and anti-oxidation
• formation skin protection layer after use
• Prevent skin irritation by soothe materials
• Containing natural fragrance to relax the skin
• Protect the skin from harmful environment

Main ingredients
7 kinds of Plant extracts compound
To Use
Wet face with warm water. Pump a generous amount
of cleanser into the palm. Massage gently in a
circular motion over the entire face. Rinse
thoroughly, pat dry.
180ml
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Product Characteristic
Sensitive Skinewal Toner
Provide nutrition and maintain skin balance Low
irritation and Weak acid Toner
Characteristic

• Containing K6PC-5 Liposome
• Maintain skin pH balance
• Maintain ideal water balance
• Full moisturizing and emollient effect

Main ingredients
K5, Inulin, Niacinamide, Portulaca oleracea
Extract, Glucan, Sodium hyaluronate
To Use
After wash the face, apply to entire face with a
cotton ball or cotton square
150ml
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Product Characteristic
Sensitive Skinewal Emulsion
Provide nutrition and maintain skin balance Low
irritation and Weak acid Emulsion
Characteristic

• Provide Anti-Aging effect by K6PC-5
• Promote skin penetration by MLE Formulation
• Maintain skin balance
• Formation protection layer on the skin

Main ingredients
K5, Ceramide, Niacinamide, Greentea seed oil,
Glucan
To Use
After toner, apply to entire face and neck.
150ml
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Product Characteristic
Sensitive Skinewal Day Cream SPF10
Moisturizing and UV protection during the day
time
Characteristic

• No sticky and greasy MLE formulation
• UV protection / SPF10
• Provide Long term moisturizing and skin
  tightening effect
• Improve rough skin and formation protection
  layer on the skin.

Main ingredients
Anti-UV  Ethylhexyl methoxycinnamate ,
Ethylhexyl salicylate ,Octocrylene
k5,Lactoglobulin , Hydrolyzed extensin , Inulin,
hyaluronate, Xanthan gum, Ceramide, Niacinamide,
Portulaca oleracea Extract
To Use
In the mongning, apply to entire face and neck in
the final step of skincare.
50ml
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Product Characteristic
Sensitive Skinewal Night Cream
Provide moisturizing, nutrition and tightening
during the night time High concentrated Balm
type Cream
Characteristic

• Rich high concentrated Balm type night cream
• Prompt skin rejuvenating effect by Panthenol
• Activating the weary skin caused by stress and
  UV
• Recovering the harmful skin barrier function by
  Ceramide

Main ingredients
Panthenol , K5, Ceramide , Inuline , Hydrolyzed
extensin, Olive butter
To Use
In the night, apply to entire face and neck in
the final step of skincare.
50ml
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Product Characteristic
Sensitive Anti-Aging Activator
Total Anti-Aging treatment to reduce the
wrinkles, freckles and black spots
Characteristic

• Containing K6PC-5,Arbutin, Peptide to improve
  skin problems likes wrinkles and freckles.
• Skin friendly MLE formulation and low irritation
  skin treatment cream

Main ingredients
K5, Amino acid, Arbutin, Ascorbyl Pentapeptide,
Ceramide Herb extracts compound, 7 plants
extract compound, Portulaca oleracea Extract
To Use
After Toner Emulsion, apply to entire face and
neck. Pay special attention to the areas with
fine lines, roughness, wrinkles, laugh lines.
30ml
22
Product Characteristic
Sensitive Anti-Aging Eye Serum
Low skin irritation Total Anti-Aging Eye Care
Reduce the wrinkles on the eyes and lips areas.
Characteristic

• Silicon complex with K5, Arbutin, Peptide
• Focused on wrinkles on the eyes and lips areas.

Main ingredients
K5 , Arbutin, Ascorbyl Pentapeptide, Ceramide ,
Niacinamide, Sodium hyaluronate
To Use
After Toner Emulsion, apply to eyes and lips
areas. Pay special attention to the fine lines
and laugh lines.
15ml
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Product Characteristic
Sensitive Skinewal Facial mask
High concentrated Soothing moisturizing
Essential mask with Anti-Aging Activator and
pseudo Ceramide (PC-9S)
Characteristic

• High concentrated Essential mask with Anti-Aging
  Activator
• Ceramide and Plants extract sooth the skin

Main ingredients
K5 Liposome, Ginko Biloba Extract, Witch Hazel
Extract,  Betaine , Sodium hyaluronate
To Use
After toner, gently over entire face. Remain for
20 to 30 minutes.
6 sheets
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Product Characteristic
Sensitive Skinewal Eye gel sheets
Containing Repair active and Pseudo Ceramide
Hydrogel sheet for eyes treatment
Characteristic

• High concentrated Hydrogel eye sheet with
  Anti-Aging Activator
• Ceramide and Plants extract sooth the skin

Main ingredients
K5 liposome , Ginko biloba extract , Witch hazel
extract, Betaine ,Sodium hyaluronate
To Use
After toner, remove the plastic seal and apply
each patch under eyes or arounds lips for
2030mins.
10 sheets
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Sample Composition
Promotion Sample
Sensitive Anti-Aging Eye Serum 1m Sensitive
Anti-Aging Activator 1ml Sensitive Skinewal
Toner 8ml Sensitive Skinewal Emulsion
8ml Sensitive Skinewal Toner 30ml
Sensitive Skinewal Emulsion 30ml
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Launching Package
Sensitive Skinewal Skincare Set
Sensitive Anti-Aging Eye Serum 1m Sensitive
Anti-Aging Activator 1ml Sensitive Skinewal
Toner 8ml Sensitive Skinewal Emulsion
8ml Sensitive Skinewal Toner 30ml
Sensitive Skinewal Emulsion 30ml

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Step for Use
Day care
Make up
Toner
Foam Cleanser
Eye Serum
Emulsion
Activator
Day Cream
Night care
Toner
Foam Cleanser
Eye Serum
Emulsion
Activator
Night Cream
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Step for Use
Special Facial Treatment (12 time / week)
Toner
Eye Serum
Facial Mask
Activator
Special Eye Treatment (12 time / week)
Toner
Eye Serum
Activator
Emulsion
Eye gel sheet
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BIO-NANO TECH IN USA ????.????????? ???81366?????
?422-1? TEL[phone] FAX[phone]