Simulating population genetics

1
Simulating population genetics

• review of very basic genetics
• genes
• alleles
• chromosomes

2
Why study this?

• Agriculture
• Understanding relationship between species
• Understanding propagation of genetic diseases
• Understanding history of evolution, human
  migration, human diversity

3
Approaches, pros and cons

• Field experiment
• Mathematical model
• Simulation

4
Simplest model

• A little history, Mendelian laws
• Hardy-Weinberg equilibrium
• A little probability/statistics
• Wahlund effect in segregated population
• Example Da Cunhas data on Drosopila polymorpha
  abdomen color Smi89
• Assignment 1 goal, limitations of theoretical
  model

5
Gregor Mendel (1822 - 1884)
6
http//bio.winona.edu/berg/241f00/Lec-note/Mendel.
htm, Steven Berg, Winona State
7
www.nd.edu/hholloch/pi.html, Hope Holloche, U.
Chicago