MIXED POPULATION

1
Selection for an Ideal Population for
Transplantation Expectations and Results
Past Studies BEHAVIORAL IMPROVEMENT IN
PARKINSONS DISEASE ANIMAL MODEL TERATOMA
FORMATION
expansion differentiation
transplantation
MIXED POPULATION
SELF-RENEWING EMBRYONIC STEM CELL
FACS for eGFP
Predicted Result BEHAVIORAL IMPROVEMENT WITH NO
TERATOMA FORMATION
transplantation
Actual Result PRESENCE OF A MIXED POPULATION NO
BEHAVIORAL IMPROVEMENT WITH TERATOMA FORMATION
PURE/FUNCTIONAL POPULATION
2
Figure 1 Simplistic depiction of a totipotent
Embryonic Stem Cell and its possible
differentiation pathways. In theory, totipotent
Embryonic Stem Cells can give rise to all types
of cells from all types of tissues, therefore the
illustration above is just one of many
possibilities.
self-renewal
ESC-Embryonic Stem Cell
Embryonic Stem Cell-Exact copy of original ESC.
Induction of Growth Factors and Multiple cell
divisions.
Progenitor Cells (Differentiation)
Hematopoietic Progenitor
Neuronal Progenitor
Specialized Cells
(Commitment)
Astrocyte
Macrophage
Neuron
3
Figure 2 Stem Cell Self-Renewal and Asymmetric
Division
A.) Parental Stem Cell
self-renewal
B.) Self-Renewed Daughter Cell
C.) Daughter Cell
D.) Differentiated Adult Cells