Industrialization of Biology

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Industrialization of Biology

• Innovate, Automate and Simplify

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What does Beckman Coulter see as its major
opportunity?

• Automated solutions What drives that is the
  high labor required of testing in both life
  sciences research laboratories and clinical
  laboratories.
• Automating those processes increases
• efficiency
• safety
• and ...
• the quality of the answer.
• So automated solutions is one driver we see
  for almost all our businesses and it's one of the
  major opportunities.
• - Jack Wareham Originally Published IVD
  Technology March 2001

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Faster Processing
Chiron Corporation's Genomic Process
Biomek FX
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Time Savings
Biomek 2000
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Manual
72
0
10
20
30
40
50
60
70
Weeks
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Transitioning to Automation
If you want to mess a lot of things up in a hurry
use automation.. If you want to create a huge
amount of reliable data in a hurry use automation
correctly!
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Project Planning Success

Desired Results
Pain
Time
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Implementing Automation

• Define and prioritize
• The needs of the organization
• The processes which are currently used to meet
  those needs
• The expectations and requirements for success
  (ROI)
• The feasibility/ economy of automating the
  process (engineering)
• The process(es) that will be first approached
• Identify
• The appropriate technologies to address the set
  goals
• Outline a timetable for implementation and
  training
• Implement the automation
• Validate and verify

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Defining the Process
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Forms of automation

• Task Targeted Automation
• vs.
• Total Automation

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Beckman Coulters GenomeLabTM - A Task Target
Approach

• Centrifugation

• Automation

• Cytometry

General Genetic Analysis i.e. Genotyping Sequen
cing

• Clinical
• Testing

Continued Analysis i.e. SNP Detection Gene
Expression
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Beckman Coulters Assay WorkstationTM - A
Total Automation Approach
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Integrated Workstations
Detectors
Real-Time PCR
Centrifuges
Nanoliter Dispensors
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Automating Workflow
Data extracted from SQL server or other Data
Source
Data may be used to track samples through the
work process or to dictate the appropriate work
process to follow
Meta-data May be exported back to SQL Server
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Elements of a Solution
Sample Transport
Liquid Handling


Support



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Words from our current CEO
We are on the threshold of great achievement
as we embrace the challenge to save lives and
improve the economics of health care. - Scott
Garrett

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Resources

• Several websites organizations offer a good
  deal of information regarding laboratory
  automation in a generally unbiased manner.
• User information/ discussion
• The Laboratory Robotics Interest Group
  http//www.lrig.org/
• Comparative Shopping -
• Drug Discovery Development http//www.dddmag.c
  om
• Biocompare http//www.biocompare.com/
• Critical evaluations of lab automation
  (general)
• American Association for Clinical Chemistry
  http//www.aacc.org/
• College of American Pathologists
  http//www.cap.org
• Market Analysis of Automation Vendor
• Frost Sullivan
• http//www.frost.com/prod/servlet/report-brochure
  .pag?idA762-01-00-00-00
• General Search Terms
• Liquid Handling Robotics, High Throughput
  Screening, Laboratory Automation, Automated
  Sample Handling, Assay Automation,