Jan 2006 CDRP Progress Report Laredo Grant

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Jan 2006 CDRP Progress Report Laredo Grant
Evaluating Cancer Disparities Among Hispanic
Communities
Bobby Bains MD, PI
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Research Organizational Chart
Charles Thomas UTHSCSA
Dr. Tony Eng UTHSCSA
NCI Laredo Cancer Disparities Grant Y Bains,
MD Principal Investigator
GI
Public Health / Screening
Charles Thomas UTHSCSA
LUNG
Maria Fernandez UT School of Public Health
N A V I G A T I O N
Anuja Jhingran MDA
GYN
Communication Effectiveness
Y Bains MD LMC, UTHSCSA
Mets
Melinda Villagran UTSA Dept of Communication
CDRP TRIALS
Gary Unzeitig Breast Surgeon
Breast
Community Outreach
Daniel G. Petereit Rapid City Regional Hospital
Singing River Hospital
Eduardo Miranda Med. Oncology
Chemo
Oscar Munoz Texas AM Colonias Program
HDR Prostate Study
Amifostine Study
Ian Thompson UTHSCSA
GU
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CDRP Clinical Trials

• 8 Clinical Trials to date
• 5 Open and Active
• 1 Study NOT approved by local IRB
• 2 Closed Studies
• 13 total patients accrued

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Open and Active Clinical Studies

• NCIC MA20 A Phase III Study of Regional Therapy
  in Early Breast Cancer -- 4 patients enrolled
• A Pilot Study of Hypo-Fractionated External Beam
  Radiation and HDR Brachytherapy for Advanced
  Prostate Cancer. ( CDRP Trial, Dan
  Petereit PI ) -- No patients. Urologists not
  on board
• Pilot Trial of Enbrel in Patients with
  Cancer-associated Fatigue and Cachexia Receiving
  External Beam Radiotherapy. (Inhouse Trial, C
  Thomas PI) -- 1 patient enrolled
• Open-Label, Multicenter Prospective Trial
  Evaluating the Reduction of Treatment Breaks with
  Ethyol in Patients with Measurable, Unresectable
  NSCLC. (R. Wynn PI) -- 2 patients enrolled
• A Prospective, Randomized Pilot Study of
  Melatonin vs. Placebo to Reduce Skin Toxicity and
  Treatment Breaks in Breast Cancer Patients
  Treated with Conservative Surgery and Radiation
  Therapy. (Inhouse Trial, Y. Bains PI). Awaiting
  DSMB final approval/Web registration setup

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Closed Clinical Studies

• RTOG 0122 A Double-Blind Study of Nutritional
  Intervention for the Treatment of Cancer Cachexia
  Using Juven Nutritional Supplement. (6 pts
  enrolled) Trial closed / completed accrual
• RTOG BR 0118 A Phase III Study of Conventional
  Radiation Therapy Plus Thalidomide (NSC 66847)
  Versus Conventional Radiation Therapy for
  Multiple Brain Metastases. protocol closed by
  RTOG soon after local IRB approval obtained

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Study NOT approved by LOCAL IRB

• NSABP B-39 / RTOG 0413 A Randomized Phase III
  Study of Conventional Whole Breast Irradiation
  (WBI) Versus Partial Breast Irradiation (PBI) for
  Women with Stage 0, I, and II Breast Cancer

IRB Recommendation Surgeon, Radiation
Oncologist, Physicist to perform 5 placements of
Mammosite Catheter and Treatment OFF protocol to
demonstrate competence.
Status Update 2 placements of Mammosite
completed. Confounding factor BC/BS of Texas
NOT covering cost of surgical placement/mammosite
balloon.
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Navigator Studies

• 5 Navigator Studies to date
• 3 studies completed
• 1 Closed accrual continue to follow up
• 1 open and active
• 877 Total subjects in studies
• 600 Approximate Navigation Visits to date
• 168 Total Navigation Visits in 2005

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Navigator Studies

• San Antonio Center of Biomarkers of Risk for
  Prostate Cancer (SABOR). (300 pts.) closed to
  new accruals, follow up on previous subjects
  only
• FREE MAMMOGRAM PROGRAM IN COLONIAS A
  Communication Effectiveness Study. Oct-May 2004
  (36 subjects)
• Evaluating Colorectal Cancer Screening Among Low
  Income Hispanics (Focus Groups members 32 200
  surveys)
• CANCER SURVEY IN COLONIAS Awareness, Perception,
  and Knowledge of Cancer Among Hispanics in
  Colonias. June-July 2005 (300 subjects)
• STAR Study of Tamoxifen and Raloxifene for the
  prevention of breast cancer. NSABP Protocol P-02
  (11 patients accrued)

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Telesynergy Use

• 4370 minutes of use from Jan 2005-Dec 2006
• Staff Training
• Meetings
• UTHSCSA Radiation Oncology Weekly Lecture Series
• UTHSCSA / CTRC Gynecology Oncology Weekly Tumor
  Boards

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(No Transcript)
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PUBLICATION

• Fernandez ME, Torres I, Vernon S, Byrd T,
  Hinojosa-Lindsey M, Wippold R, Bains Y.
  Colorectal cancer screening among Latinos from
  U.S. cities along the Texas-Mexico border a
  qualitative study. Prev Chronic Dis serial
  online 2005 Apr.

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Abstracts (posters) presented at ASTRO 05

• Barriers Faced by Mexican American Patients
  During Radiation Therapy Preliminary Results of
  the Laredo Navigator Project of the NCI U56
  Cancer Disparities Research Partnership Program.
  Bains, Yadvindera Guajardo, Jessica O. Cerda,
  Melissa Thomas, Charles R.
• Preliminary Investigation of Preferred Mediated
  and Interpersonal Sources of Health Information
  Among Low-income Hispanic Women Receiving
  Mammograms The Laredo NCI U56 Health Care
  Disparities Navigator Program. Villagran,
  Melinda Bains, Yadvindera S., Guajardo, Jessica
  Munoz, Oscar Thomas, Charles.

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• THANK YOU !