Protein Ubiquitinylation

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Protein Ubiquitinylation
Creative BioMart
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As a leading biotechnology services
supplier, Creative BioMart offers protein
ubiquitinylation services. With our expertise as
a leader in the field of ubiquitinylation
services, Creative BioMart has created a set of
new platform technologies.
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Creative BioMart provides compound screening and
profiling against E3 ligase cascades. Each
ubiquitination cascade consists of the three
enzyme components (E1 activating enzyme, E2
conjugating enzyme and E3 ligase), plus a
biologically-relevant substrate. The
incorporation of ubiquitin into the substrate is
quantitatively detected by electrochemiluminescenc
e, which allows for the identification of
compound inhibitors and activators.
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Highlights

• Validated assays for an expanding panel of E3
  ligase cascades to screen and profile inhibitors
  and enhancers.
• Cascades consist of E1, E2 and E3 enzymes and
  substrates.
• Uses biologically relevant substrate.
• Single or multiple concentration.
• Run by the same experts who have run many years
  experience.

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Ubiquitin E3 Ligase Identification Service
Creative BioMart employs a high-content
microarray and ubiquitin pathway expertise to
identify candidate E3's that are capable of
ubiquitylating your substrate
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The service includes the following steps

• A high-content, functional microarray is probed
  with client's substrate.
• Probe microarray with antibody to client's
  substrate or associated tag. Direct labeling of
  the protein is available for detection.
• Locations of substrate binding indicate
  E3-substrate interactions and potential E3
  enzymes that ubiquitylate client's substrate.

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About Creative BioMart
Starting from a small supplier of proteins and
enzymes for academic institutes and biotech
companies, Creative BioMart has always been
focusing on developing high quality protein
products including recombinant protein, GMP
proteins, native proteins, assay kit, etc. and
efficient protein service. Over the past decade,
our products and services are proved to have
served our customers well and our brand has
become one of the most trustworthy in the market.
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Thanks for watching! Contact Creative
BioMart Address 45-1 Ramsey Road Shirley, NY
11967, USA Email contact_at_creative-biomart.com W
ebsite http//www.creativebiomart.net