TandAb - PowerPoint PPT Presentation
Title:
TandAb
Description:
TandAb (Tandem diabody) is a type of bispecific antibody fragments. TandAb is a tetravalent bispecific molecule, 2+2 antigen-binding valency, consisting solely of Fv domains. TandAb is expressed as a monomeric subunit (single chain Diabody, scDb) with four variable domains from two parental antibodies. In the subunit, the linkers are too short to form intra-chain pairing, so the 2 polypeptides dimerize in a head-to-tail fashion. TandAbs have been studied as BiTEs (bispecific T cell engagers) or BiKEs (bispecific NK engagers) in tumor immunotherapy. – PowerPoint PPT presentation
Number of Views:12
Title: TandAb
1
Reference https//www.creative-biolabs.com/bsab/c
ategory/tandab-37.htm
2
What is TandAb?
3
Figure Diagram of tandem diabody procedure
(Mabs, 2014)
4
The moderate size also endows TandAb a better
tissue penetrating ability and longer serum
half-life than the former and the latter formats
repectively. In addition, the tetravalent
property, which means bivalent for each antigen,
can significantly improve its binding efficiency
and consequent therapeutic outcome. In present
medical application, tandem diabodies are mainly
utilized in recruiting NK cells and macrophages
to tumors. Thus, its outstanding properties can
undoubtedly be applied in broader fields.
5
(No Transcript)
