Title: Multiple Endocrine Neoplasia - Symptoms, Causes, and Treatment
1Multiple Endocrine Neoplasia - Symptoms, Causes,
and Treatment
2What is Multiple Endocrine Neoplasia?
- Multiple endocrine neoplasia, type 1 (MEN 1),
sometimes known as Wermer's syndrome, is an
unusual disorder that causes tumors in the
endocrine glands and parts of the small intestine
and stomach. In MEN 1, the endocrine glands
generally the parathyroids, pancreas, and
pituitary grow tumors and release excessive
amounts of hormones that could result in disease.
Although, the tumors are generally non-cancerous
(benign). - The excess hormones could cause a wide variety of
signs and symptoms. These could involve
tiredness, bone pain, broken bones, kidney
stones, and ulcers in the abdomen or intestines.
MEN 1 cannot be cured. But regular testing can
find out problems, and doctors can provide
treatment as required. - MEN 1 is a hereditary disorder. This means people
who have the gene mutation could pass it on to
their children. Each child has a fifty percent
chance of getting the disorder.
3Symptoms of Multiple Endocrine Neoplasia
- Signs and symptoms of MEN 1 are as follows
- Â Â Â Tiredness
- Â Â Â Bone pain
- Â Â Â Broken bones
- Â Â Â Kidney stones
- Â Â Â Ulcers in the stomach or intestines
- Symptoms are caused by the release of too many
hormones into the body.
4Diagnosis of Multiple Endocrine Neoplasia
- To diagnose multiple endocrine neoplasia, type 1
(MEN 1), your doctor will conduct a physical
examination and check your medical history and
family history. You might have a blood test and
imaging tests, including the following - Â Â Â Magnetic resonance imaging (MRI)
- Â Â Â Computerized tomography (CT) scan
- Â Â Â Positron emission tomography (PET) scan
- Â Â Â Nuclear medicine scans
- Â Â Â Endoscopic ultrasound of the pancreas and
other tests
5Genetic testing might determine whether someone
has a genetic mutation causing MEN 1. If someone
has a mutation, his or her children are at risk
of getting the mutation and developing MEN 1.
Parents and siblings also are at risk of having
the mutation though they have not yet developed
any symptoms. If no associated genetic changes
are found in family members, then no further
screening tests are required. Although, genetic
testing does not uncover all MEN 1 genetic
mutations. If genetic testing does not confirm
MEN 1, but it is likely a person has it, that
person and their family members still require
close follow-up with appropriate blood and
imaging tests. Continue To Read More Click
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