Prospective cohort studies | research process | Clinical Case Study Report Writing

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HOW TO FRAME A RESEARCH QUESTION AND SUB-RESEARCH
QUESTION FOR PROSPECTIVE COHORT STUDIES
An Academic presentation by Dr. Nancy Agnes,
Head, Technical Operations, Pubrica Group
www.pubrica.com Email sales_at_pubrica.com
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Introduction

• Framing a research question for prospective
  cohort studies requires careful consideration of
  the specific research topic and population of
  interest.
• Here are some steps to follow to frame a research
  question and sub-questions for prospective cohort
  studies
• 1.Identify the main research question The main
  research question should be a focused,
  hypothesis-driven question that clearly defines
  the research objective.
• 2.Define the population of interest The research
  question should clearly define the population of
  interest
• 3.Specify the exposure or intervention of
  interest The exposure or intervention of
  interest should be specified in the research
  question..
• 4.Consider the outcome of interest The research
  question should clearly define the outcome of
  interest.
• 5.Develop sub-questions Sub-questions can be
  used to provide more detail and clarity to the
  main research question.

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Example research question Does regular physical
activity reduce the risk of cardiovascular
disease among middle-aged adults over a 10-year
period, compared to sedentary ones?
Sub-questions

• What is the incidence rate of cardiovascular
  disease among the study population over the 10
  years?
• What is the level of physical activity among the
  study population, and how does it vary over time?
  
• What are the demographic and lifestyle
  characteristics of the study population, and how
  do they influence the risk of cardiovascular
  disease?
• How does the risk of cardiovascular disease vary
  according to different levels of physical
  activity after controlling for other demographic
  and lifestyle factors?
• What is the dose-response relationship between
  physical activity and the risk of cardiovascular
  disease among middle-aged adults over a 10-year
  period?

contd...
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• Some possible research objectives based on the
  research question
• To investigate the incidence rate of
  cardiovascular disease among middle-aged adults
  over a 10-year period.
• Assess the level of physical activity among the
  study population and how it varies over time.
• To examine the demographic and lifestyle
  characteristics of the study population and how
  they influence the risk of cardiovascular
  disease.
• After controlling for other demographic and
  lifestyle factors, determine the relationship
  between physical activity and cardiovascular
  disease risk among middle-aged adults.
• To explore the dose-response relationship between
  physical activity and the risk of cardiovascular
  disease among middle-aged adults over a 10-year
  period.

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About Pubrica

• The team of researchers and writers at Pubrica
  creates scientific and medical study papers that
  can serve as invaluable resources for
  practitioners and authors.
• Using the reader to inform them of the gaps in
  the chosen study area, Pubrica medical writers
  assist you in writing and editing the
  introduction.
• Our specialists are conscious of the order in
  which the general topic, the issue, and the
  background are followed by the narrow subject
  where the hypothesis is stated.

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