Risk Factors of Rheumatoid arthritis

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Understanding Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune
disease causing the immune system to mistakenly
attack its tissues. It primarily affects the
synovium, the lining of the membranes surrounding
the joints. Symptoms include joint pain,
swelling, stiffness, and eventual joint
damage. At Indias top regenerative
rehabilitation centre, we offer customized and
holistic rehabilitation programs to manage RA
effectively.
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Risk Factors of Rheumatoid Arthritis

• Genetic Risk Factors
• Genetic Predisposition Significant role in the
  development of RA. Certain genetic markers, like
  the HLA-DRB1 gene, are strongly associated with
  increased susceptibility. Family history of RA
  increases the likelihood of developing the
  condition.
• Gender and Age Risk Factors
• Gender RA is more prevalent in women than men.
  Hormonal differences contribute to this
  disparity. Women are two to three times more
  likely to develop RA.
• Age Onset is most common between ages 40 and 60.
• Juvenile rheumatoid arthritis (JRA) affects
  children, indicating RA is not confined to older
  adults. Risk factors for JRA are similar to
  late-onset RA, with family history playing a key
  role.

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Risk Factors of Rheumatoid Arthritis

• Lifestyle Risk Factors
• Smoking Increases likelihood of developing RA
  and exacerbates its severity. Smokers with RA
  experience more severe symptoms and faster
  disease progression.
• Obesity Excess weight stresses joints and
  produces pro-inflammatory cytokines.
• Gum Disease Significant factor in RA, lung
  disease, heart disease, and Alzheimers. Harmful
  bacteria can lead to severe inflammation in the
  lungs and joints.
• Diet Avoiding red meat, dairy, sugar, and
  high-fructose syrup while emphasizing fish,
  vegetables, and olive oil can help prevent
  arthritis.
• Changes in the Microbiome Imbalances in gut and
  oral microbiomes can lead to inflammation and RA.
  Factors like diet, antibiotics, and lifestyle can
  disrupt this balance.

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• Environmental Risk Factors
• Exposure to Toxins Asbestos, silica, and
  pesticides linked to increased RA risk. These
  toxins trigger chronic inflammation and
  autoimmune responses.
• Infections Epstein-Barr virus and hepatitis C
  are associated with higher RA risk. Infections
  alter immune function and trigger autoimmune
  responses.
• Air Pollution Chronic exposure to fine
  particulate matter causes systemic inflammation,
  contributing to RA development.

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Rheumatoid Arthritis Precautions

• Healthy Diet Anti-inflammatory foods like
  omega-3 fatty acids (fish, flaxseeds, walnuts)
  reduce inflammation. Antioxidant-rich fruits and
  vegetables support overall health.
• Regular Exercise Low-impact exercises (swimming,
  walking, yoga) maintain joint flexibility and
  reduce inflammation. Strength training supports
  joint health by strengthening surrounding
  muscles.
• Quitting smoking Quitting smoking is crucial as
  it worsens RA progression and reduces treatment
  effectiveness. Avoiding smoking improves health
  outcomes for RA patients.
• Weight Management Maintaining a healthy weight
  reduces joint stress, inflammation, and pain.
• Diet and exercise alleviate symptoms and improve
  quality of life.

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Stem Cell Therapy at Plexus

• At Plexus, we use mesenchymal stem cells (MSCs)
  to suppress inflammation and mediate
  immunomodulation. MSCs are sourced either from
  donors or from the patients own body. They are
  typically isolated from adipose tissue, bone
  marrow, and umbilical cord tissue.
• Key Properties of MSCs
• Anti-Inflammatory Effects Reduce localized
  inflammation in the joints
• Immunomodulation Regulate the immune system by
  suppressing inflammatory responses
• Tissue Regeneration Differentiate into bone and
  cartilage cells to repair damaged tissues
• Low Risk of Immune Rejection Generally
  well-tolerated by the immune system

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• Comprehensive Care at Plexus
• In addition to stem cell therapy, our customized
  rehabilitation for RA also features the
  following
• Physical therapy, occupational therapy, nutritive
  therapies, pain management
• Fall prevention training, emotional counseling,
  caregiver support
• Other therapeutic interventions to help patients
  live a full and pain-free life

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Understanding and addressing RA risk factors aids
in early detection and better management. Lifestyl
e modifications like quitting smoking,
maintaining a healthy weight, and following a
balanced diet reduce RA risk and impact. Contact
Plexus for more information on our rehabilitation
program for rheumatoid arthritis. WhatsApp 91
89048 42087 Call 91 78159 64668 (Hyderabad)
91 82299 99888 (Bangalore)