MSC Therapy for Rheumatoid Arthritis - Plexus

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• Understanding Rheumatoid Arthritis
• Rheumatoid Arthritis (RA) is an autoimmune
  disease where the body's immune system attacks
  its own tissues, especially in the joints.
• The inflammation affects the synovium (lining of
  the joints), causing pain, swelling, and
  stiffness.
• Over time, this can lead to joint deformities and
  loss of mobility.
• Systemic symptoms include
• Fatigue
• Low-grade fever
• Unintended weight loss
• Respiratory and cardiovascular complications
• Increased risk of osteoporosis

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• Diagnosis and Treatment of RA
• The following tests are typically conducted to
  conclusively diagnose
• Blood tests (e.g., rheumatoid factor, anti-CCP
  antibodies)
• Imaging (X-rays, ultrasound, MRI) to assess joint
  damage
• Conventional approach to treat RA include
• Medications
• DMARDs (Disease-modifying antirheumatic drugs)
  Methotrexate, hydroxychloroquine (slows
  progression but with potential side effects)
• NSAIDs (Nonsteroidal anti-inflammatory drugs)
  Ibuprofen, naproxen (provides pain relief but
  does not address root cause)
• Corticosteroids Prednisone (short-term relief
  for flare-ups)
• Biologic DMARDs Infliximab, adalimumab (target
  immune system, but expensive and carry risk of
  infections)
• Physical and Occupational Therapy
• To maintain joint flexibility and function
• Occupational modifications to reduce strain
• However, these treatment approaches come with
  their own set of side effects owing to long-term
  medication use. Additionally, they do not follow
  a personalised and patient-centric approach.

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The Promise of Stem Cell Therapy What are stem
cells? Undifferentiated cells capable of
transforming into any tissue type (e.g., bone,
cartilage, muscle). Their regenerative properties
make them ideal for treating conditions like
RA. Stem cell therapy is a type of regenerative
medicine that helps repair damaged tissues,
reduce inflammation, and modulate the immune
system. It is known to address the root causes of
RA, not just its symptoms.
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• The Mechanism of Mesenchymal Stem Cell Therapy
• Isolated from various sources, such as adipose
  tissue (fat), bone marrow, and umbilical cord
  tissue, Mesenchymal Stem Cells (MSC)have the
  following key properties that make them promising
  for treating RA
• Anti-Inflammatory Effects MSCs have the
  potential to produce anti-inflammatory molecules
  that help reduce localized inflammation in the
  joints.
• Immunomodulation MSCs can regulate the immune
  system by suppressing inflammatory responses that
  damage the joints.
• Tissue Regeneration MSCs can differentiate into
  various cell types, such as bone and cartilage
  cells, thereby aiding in repairing damaged
  tissues (in the joints).
• Low Risk of Immune Rejection MSCs are generally
  well-tolerated by the immune system.
• Stem Cells Translational Medicine , a study
  published in 2020, showcases how intravenous MSC
  administration reduced inflammation and disease
  activity in RA patients.

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• MSC Therapy at Plexus
• As Indias no. 1 regenerative rehabilitation
  centre, Plexus offers a customised and holistic
  approach to managing rheumatoid arthritis. We use
  autologous mesenchymal cells that are procured
  from the patients body to suppress inflammation
  and mediate immunomodulation.
• MSCs are collected from adipose tissue, bone
  marrow, or umbilical cord, and then injected
  either intravenously or directly into the
  affected joints
• We also offer physical therapy, emotional
  support, and follow-up care for holistic recovery
• Why choose MSC Therapy at Plexus?
• Long-Term Relief Patients often report lasting
  improvements in mobility and pain management.
• Minimal Risk of Rejection Use of autologous
  cells reduces rejection rates.
• Holistic Support Integrative approach including
  physical therapy, pain management, and emotional
  support.

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Reach Out to Us Today, Plexus is leading the way
in providing innovative, effective, and safe stem
cell treatments in India. To know more about
mesenchymal stem cell therapy and how it can
improve the lives of those affected by rheumatoid
arthritis, reach out to Team Plexus
today. WhatsApp [phone] Call 91
9513262686 (Hyderabad) 91 9355533404
(Bangalore)