Analysis of Human Exhaled Breath using the Mass Spectrometer

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Analysis of Human Exhaled Breath using the Mass
Spectrometer
Airsense
Gas-phase analysis of exhaled breath as
information carrier of passing processes
in man
Analyse- und Messtechnik GmbH
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Range of Use

• Medical Diagnostics
• Provocation Tests
• Pharmaceutics
• Workplace Monitoring
• Drug Analysis

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Practical Performance - online
Online analysis of the exhaled breath after
take up of a natural product containing drug
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Practical Performance offline
? Sampling by exhalation into a vial that
is crimped afterwards
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Practical Performance offline
? Conditioning and measurement of up to 200
masses in consideration of the ambient
air when sampling ? Differential
measurement between 1 sample vial and 1
ambient air vial
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Evaluation

• ? Standardization to the exhaled quantity of CO2
• Standardization to the maximum value of all
  samples per mass ? relative range of values 0
  1
• Comparison of maximum- and minimum values to a
  large data pool

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Results
Each ? resp.? represents one patient outside the
average area
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Features of the VF-Mass Spectrometer Airsense

• Concentrations lt 0.001 ppm up to Vol
• All relevant organic and inorganic compounds
• resp. compound classes detectable
• Time of analysis
• - online 300 msec per compound
• - offline ? 5 sec per compound
• Simple sampling ? autosampler
• No pre-concentration of the samples
• Long sample shelf life

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Advantage of the Airsense in Comparison to
Classical Methods
? Non-invasive ? Easy to handle,
safe ? Quick ? Versatile ? Fully automated
procedure for analysis and data
evaluation ? Quality-assured ? Cost-efficient
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Conclusion
? Systematical investigation of volatile
compounds in human exhaled breath e.g.,
ammonia, methane, acetone, isoprene, alcohols,
aldehydes, ketones, carboxylic acids, amines
etc. ? Fast online and offline-analysis of
exhaled breath ? Diagnostics from the range of
values of the data- pool
Analyse- und Messtechnik GmbH